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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
q13.43
Chromosome location (bp)
56810077 - 56840728
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003674[molecular_function] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005776[autophagosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0010468[regulation of gene expression] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003674[molecular_function] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005776[autophagosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0010468[regulation of gene expression] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003674[molecular_function] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005776[autophagosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0010468[regulation of gene expression] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003674[molecular_function] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005776[autophagosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0010468[regulation of gene expression] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003674[molecular_function] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005776[autophagosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0010468[regulation of gene expression] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003674[molecular_function] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005776[autophagosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0010468[regulation of gene expression] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003674[molecular_function] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005776[autophagosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0010468[regulation of gene expression] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003674[molecular_function] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005776[autophagosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0010468[regulation of gene expression] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003674[molecular_function] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005776[autophagosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0010468[regulation of gene expression] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003674[molecular_function] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005776[autophagosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0010468[regulation of gene expression] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003674[molecular_function] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005776[autophagosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0010468[regulation of gene expression] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003674[molecular_function] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005776[autophagosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0010468[regulation of gene expression] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
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