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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
CD markers Disease related genes FDA approved drug targets Human disease related genes Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q23.3
Chromosome location (bp)
118304730 - 118316175
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways 1. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region 2,3....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Adaptive immunity, Immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0001772[immunological synapse] GO:0001954[positive regulation of cell-matrix adhesion] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0002669[positive regulation of T cell anergy] GO:0002870[T cell anergy] GO:0004888[transmembrane signaling receptor activity] GO:0005515[protein binding] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0007166[cell surface receptor signaling pathway] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007172[signal complex assembly] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007224[smoothened signaling pathway] GO:0009897[external side of plasma membrane] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016358[dendrite development] GO:0017124[SH3 domain binding] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019722[calcium-mediated signaling] GO:0019901[protein kinase binding] GO:0021549[cerebellum development] GO:0030159[signaling receptor complex adaptor activity] GO:0031295[T cell costimulation] GO:0032729[positive regulation of interferon-gamma production] GO:0032743[positive regulation of interleukin-2 production] GO:0032753[positive regulation of interleukin-4 production] GO:0033634[positive regulation of cell-cell adhesion mediated by integrin] GO:0035739[CD4-positive, alpha-beta T cell proliferation] GO:0042098[T cell proliferation] GO:0042101[T cell receptor complex] GO:0042102[positive regulation of T cell proliferation] GO:0042105[alpha-beta T cell receptor complex] GO:0042106[gamma-delta T cell receptor complex] GO:0042110[T cell activation] GO:0042608[T cell receptor binding] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043197[dendritic spine] GO:0044297[cell body] GO:0045059[positive thymic T cell selection] GO:0045060[negative thymic T cell selection] GO:0045879[negative regulation of smoothened signaling pathway] GO:0046629[gamma-delta T cell activation] GO:0046631[alpha-beta T cell activation] GO:0046649[lymphocyte activation] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050850[positive regulation of calcium-mediated signaling] GO:0050852[T cell receptor signaling pathway] GO:0050870[positive regulation of T cell activation] GO:0065003[protein-containing complex assembly] GO:0097190[apoptotic signaling pathway] GO:2000563[positive regulation of CD4-positive, alpha-beta T cell proliferation]
The Human Protein Atlas project is funded
