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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.32
Chromosome location (bp)
33318558 - 33323016
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chaperone, Chromatin regulator, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9UER7 [Direct mapping] Death domain-associated protein 6
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A0A024RCS3 [Target identity:100%; Query identity:100%] Death domain-associated protein 6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000775[chromosome, centromeric region] GO:0001934[positive regulation of protein phosphorylation] GO:0002039[p53 binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006334[nucleosome assembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006915[apoptotic process] GO:0007254[JNK cascade] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0010468[regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016604[nuclear body] GO:0016605[PML body] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0030295[protein kinase activator activity] GO:0030521[androgen receptor signaling pathway] GO:0031072[heat shock protein binding] GO:0031396[regulation of protein ubiquitination] GO:0031625[ubiquitin protein ligase binding] GO:0034605[cellular response to heat] GO:0034620[cellular response to unfolded protein] GO:0042393[histone binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0045860[positive regulation of protein kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071276[cellular response to cadmium ion] GO:0071280[cellular response to copper ion] GO:0072738[cellular response to diamide] GO:0140037[] GO:0140416[transcription regulator inhibitor activity] GO:0140693[molecular condensate scaffold activity] GO:1901216[positive regulation of neuron death] GO:1903936[cellular response to sodium arsenite]
Q9UER7 [Direct mapping] Death domain-associated protein 6
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A0A024RCS3 [Target identity:100%; Query identity:100%] Death domain-associated protein 6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000775[chromosome, centromeric region] GO:0001934[positive regulation of protein phosphorylation] GO:0002039[p53 binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006334[nucleosome assembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006915[apoptotic process] GO:0007254[JNK cascade] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0010468[regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016604[nuclear body] GO:0016605[PML body] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0030295[protein kinase activator activity] GO:0030521[androgen receptor signaling pathway] GO:0031072[heat shock protein binding] GO:0031396[regulation of protein ubiquitination] GO:0031625[ubiquitin protein ligase binding] GO:0034605[cellular response to heat] GO:0034620[cellular response to unfolded protein] GO:0042393[histone binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0045860[positive regulation of protein kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071276[cellular response to cadmium ion] GO:0071280[cellular response to copper ion] GO:0072738[cellular response to diamide] GO:0140037[] GO:0140416[transcription regulator inhibitor activity] GO:0140693[molecular condensate scaffold activity] GO:1901216[positive regulation of neuron death] GO:1903936[cellular response to sodium arsenite]
Q9UER7 [Direct mapping] Death domain-associated protein 6
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775[chromosome, centromeric region] GO:0001934[positive regulation of protein phosphorylation] GO:0002039[p53 binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006334[nucleosome assembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006915[apoptotic process] GO:0007254[JNK cascade] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0010468[regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016604[nuclear body] GO:0016605[PML body] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0030295[protein kinase activator activity] GO:0030521[androgen receptor signaling pathway] GO:0031072[heat shock protein binding] GO:0031396[regulation of protein ubiquitination] GO:0031625[ubiquitin protein ligase binding] GO:0034605[cellular response to heat] GO:0034620[cellular response to unfolded protein] GO:0042393[histone binding] GO:0042981[regulation of apoptotic process] GO:0045860[positive regulation of protein kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071276[cellular response to cadmium ion] GO:0071280[cellular response to copper ion] GO:0072738[cellular response to diamide] GO:0140037[] GO:0140416[transcription regulator inhibitor activity] GO:0140693[molecular condensate scaffold activity] GO:1901216[positive regulation of neuron death] GO:1903936[cellular response to sodium arsenite]
Q4VX54 [Direct mapping] Death domain-associated protein 6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Protein evidence (Ezkurdia et al 2014)
A2AB94 [Direct mapping] Death domain-associated protein 6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Protein evidence (Ezkurdia et al 2014)
Q9UER7 [Direct mapping] Death domain-associated protein 6
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775[chromosome, centromeric region] GO:0001934[positive regulation of protein phosphorylation] GO:0002039[p53 binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006334[nucleosome assembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006915[apoptotic process] GO:0007254[JNK cascade] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0010468[regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016604[nuclear body] GO:0016605[PML body] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0030295[protein kinase activator activity] GO:0030521[androgen receptor signaling pathway] GO:0031072[heat shock protein binding] GO:0031396[regulation of protein ubiquitination] GO:0031625[ubiquitin protein ligase binding] GO:0034605[cellular response to heat] GO:0034620[cellular response to unfolded protein] GO:0042393[histone binding] GO:0042981[regulation of apoptotic process] GO:0045860[positive regulation of protein kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071276[cellular response to cadmium ion] GO:0071280[cellular response to copper ion] GO:0072738[cellular response to diamide] GO:0140037[] GO:0140416[transcription regulator inhibitor activity] GO:0140693[molecular condensate scaffold activity] GO:1901216[positive regulation of neuron death] GO:1903936[cellular response to sodium arsenite]
B4E1C1 [Target identity:100%; Query identity:100%] Death domain-associated protein 6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
