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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.33
Chromosome location (bp)
31639028 - 31652705
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins 1. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation 2,3,4,5. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum 6,7,8,9. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome 10,11,12. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins 13,14,15. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum 16. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome 17. BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress 18. By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway 19....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chaperone, Chromatin regulator
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Differentiation, Immunity, Spermatogenesis, Transport
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P46379 [Direct mapping] Large proline-rich protein BAG6
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A0A1U9X7A6 [Target identity:100%; Query identity:100%] Large proline-rich protein BAG6
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001822[kidney development] GO:0002376[immune system process] GO:0002429[immune response-activating cell surface receptor signaling pathway] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006620[post-translational protein targeting to endoplasmic reticulum membrane] GO:0006915[apoptotic process] GO:0007130[synaptonemal complex assembly] GO:0007283[spermatogenesis] GO:0007420[brain development] GO:0010498[proteasomal protein catabolic process] GO:0016020[membrane] GO:0018393[internal peptidyl-lysine acetylation] GO:0030101[natural killer cell activation] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030433[ubiquitin-dependent ERAD pathway] GO:0031593[polyubiquitin modification-dependent protein binding] GO:0031625[ubiquitin protein ligase binding] GO:0031647[regulation of protein stability] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043022[ribosome binding] GO:0043231[intracellular membrane-bounded organelle] GO:0045861[negative regulation of proteolysis] GO:0045995[regulation of embryonic development] GO:0050821[protein stabilization] GO:0051787[misfolded protein binding] GO:0061857[endoplasmic reticulum stress-induced pre-emptive quality control] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070062[extracellular exosome] GO:0070628[proteasome binding] GO:0071712[ER-associated misfolded protein catabolic process] GO:0071816[tail-anchored membrane protein insertion into ER membrane] GO:0071818[BAT3 complex] GO:1904294[positive regulation of ERAD pathway] GO:1904378[maintenance of unfolded protein involved in ERAD pathway] GO:1904379[protein localization to cytosolic proteasome complex involved in ERAD pathway] GO:1990381[ubiquitin-specific protease binding]
P46379 [Direct mapping] Large proline-rich protein BAG6
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MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001822[kidney development] GO:0002376[immune system process] GO:0002429[immune response-activating cell surface receptor signaling pathway] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006620[post-translational protein targeting to endoplasmic reticulum membrane] GO:0006915[apoptotic process] GO:0007130[synaptonemal complex assembly] GO:0007283[spermatogenesis] GO:0007420[brain development] GO:0010498[proteasomal protein catabolic process] GO:0016020[membrane] GO:0018393[internal peptidyl-lysine acetylation] GO:0030101[natural killer cell activation] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030433[ubiquitin-dependent ERAD pathway] GO:0031593[polyubiquitin modification-dependent protein binding] GO:0031625[ubiquitin protein ligase binding] GO:0031647[regulation of protein stability] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043022[ribosome binding] GO:0043231[intracellular membrane-bounded organelle] GO:0045861[negative regulation of proteolysis] GO:0045995[regulation of embryonic development] GO:0050821[protein stabilization] GO:0051787[misfolded protein binding] GO:0061857[endoplasmic reticulum stress-induced pre-emptive quality control] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070062[extracellular exosome] GO:0070628[proteasome binding] GO:0071712[ER-associated misfolded protein catabolic process] GO:0071816[tail-anchored membrane protein insertion into ER membrane] GO:0071818[BAT3 complex] GO:1904294[positive regulation of ERAD pathway] GO:1904378[maintenance of unfolded protein involved in ERAD pathway] GO:1904379[protein localization to cytosolic proteasome complex involved in ERAD pathway] GO:1990381[ubiquitin-specific protease binding]
A0A7P0MQS5 [Direct mapping] Large proline-rich protein BAG6
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MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
P46379 [Direct mapping] Large proline-rich protein BAG6
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A0A1U9X7A6 [Target identity:100%; Query identity:100%] Large proline-rich protein BAG6
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822[kidney development] GO:0002376[immune system process] GO:0002429[immune response-activating cell surface receptor signaling pathway] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006620[post-translational protein targeting to endoplasmic reticulum membrane] GO:0006915[apoptotic process] GO:0007130[synaptonemal complex assembly] GO:0007283[spermatogenesis] GO:0007420[brain development] GO:0010498[proteasomal protein catabolic process] GO:0016020[membrane] GO:0018393[internal peptidyl-lysine acetylation] GO:0030101[natural killer cell activation] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030433[ubiquitin-dependent ERAD pathway] GO:0031593[polyubiquitin modification-dependent protein binding] GO:0031625[ubiquitin protein ligase binding] GO:0031647[regulation of protein stability] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043022[ribosome binding] GO:0043231[intracellular membrane-bounded organelle] GO:0045861[negative regulation of proteolysis] GO:0045995[regulation of embryonic development] GO:0050821[protein stabilization] GO:0051787[misfolded protein binding] GO:0061857[endoplasmic reticulum stress-induced pre-emptive quality control] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070062[extracellular exosome] GO:0070628[proteasome binding] GO:0071712[ER-associated misfolded protein catabolic process] GO:0071816[tail-anchored membrane protein insertion into ER membrane] GO:0071818[BAT3 complex] GO:1904294[positive regulation of ERAD pathway] GO:1904378[maintenance of unfolded protein involved in ERAD pathway] GO:1904379[protein localization to cytosolic proteasome complex involved in ERAD pathway] GO:1990381[ubiquitin-specific protease binding]
H0Y4L1 [Direct mapping] Large proline-rich protein BAG6
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DeepSig predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
P46379 [Direct mapping] Large proline-rich protein BAG6
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822[kidney development] GO:0002376[immune system process] GO:0002429[immune response-activating cell surface receptor signaling pathway] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006620[post-translational protein targeting to endoplasmic reticulum membrane] GO:0006915[apoptotic process] GO:0007130[synaptonemal complex assembly] GO:0007283[spermatogenesis] GO:0007420[brain development] GO:0010498[proteasomal protein catabolic process] GO:0016020[membrane] GO:0018393[internal peptidyl-lysine acetylation] GO:0030101[natural killer cell activation] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030433[ubiquitin-dependent ERAD pathway] GO:0031593[polyubiquitin modification-dependent protein binding] GO:0031625[ubiquitin protein ligase binding] GO:0031647[regulation of protein stability] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043022[ribosome binding] GO:0043231[intracellular membrane-bounded organelle] GO:0045861[negative regulation of proteolysis] GO:0045995[regulation of embryonic development] GO:0050821[protein stabilization] GO:0051787[misfolded protein binding] GO:0061857[endoplasmic reticulum stress-induced pre-emptive quality control] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070062[extracellular exosome] GO:0070628[proteasome binding] GO:0071712[ER-associated misfolded protein catabolic process] GO:0071816[tail-anchored membrane protein insertion into ER membrane] GO:0071818[BAT3 complex] GO:1904294[positive regulation of ERAD pathway] GO:1904378[maintenance of unfolded protein involved in ERAD pathway] GO:1904379[protein localization to cytosolic proteasome complex involved in ERAD pathway] GO:1990381[ubiquitin-specific protease binding]
A0A7I2V508 [Direct mapping] Large proline-rich protein BAG6
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MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
P46379 [Direct mapping] Large proline-rich protein BAG6
Show all
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822[kidney development] GO:0002376[immune system process] GO:0002429[immune response-activating cell surface receptor signaling pathway] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006620[post-translational protein targeting to endoplasmic reticulum membrane] GO:0006915[apoptotic process] GO:0007130[synaptonemal complex assembly] GO:0007283[spermatogenesis] GO:0007420[brain development] GO:0010498[proteasomal protein catabolic process] GO:0016020[membrane] GO:0018393[internal peptidyl-lysine acetylation] GO:0030101[natural killer cell activation] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030433[ubiquitin-dependent ERAD pathway] GO:0030544[Hsp70 protein binding] GO:0031593[polyubiquitin modification-dependent protein binding] GO:0031625[ubiquitin protein ligase binding] GO:0031647[regulation of protein stability] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042981[regulation of apoptotic process] GO:0043022[ribosome binding] GO:0043066[negative regulation of apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043231[intracellular membrane-bounded organelle] GO:0045861[negative regulation of proteolysis] GO:0045995[regulation of embryonic development] GO:0050821[protein stabilization] GO:0051787[misfolded protein binding] GO:0061857[endoplasmic reticulum stress-induced pre-emptive quality control] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070062[extracellular exosome] GO:0070628[proteasome binding] GO:0071712[ER-associated misfolded protein catabolic process] GO:0071816[tail-anchored membrane protein insertion into ER membrane] GO:0071818[BAT3 complex] GO:1904294[positive regulation of ERAD pathway] GO:1904378[maintenance of unfolded protein involved in ERAD pathway] GO:1904379[protein localization to cytosolic proteasome complex involved in ERAD pathway] GO:1990381[ubiquitin-specific protease binding]
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