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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.33
Chromosome location (bp)
31615217 - 31617021
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Actin-binding
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001726[ruffle] GO:0001774[microglial cell activation] GO:0001891[phagocytic cup] GO:0003674[molecular_function] GO:0003779[actin binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0006911[phagocytosis, engulfment] GO:0006954[inflammatory response] GO:0008284[positive regulation of cell population proliferation] GO:0010468[regulation of gene expression] GO:0016020[membrane] GO:0016601[Rac protein signal transduction] GO:0030027[lamellipodium] GO:0030041[actin filament polymerization] GO:0030046[parallel actin filament bundle assembly] GO:0030335[positive regulation of cell migration] GO:0032587[ruffle membrane] GO:0032722[positive regulation of chemokine production] GO:0032755[positive regulation of interleukin-6 production] GO:0034599[cellular response to oxidative stress] GO:0042102[positive regulation of T cell proliferation] GO:0042995[cell projection] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0048662[negative regulation of smooth muscle cell proliferation] GO:0050921[positive regulation of chemotaxis] GO:0051015[actin filament binding] GO:0051017[actin filament bundle assembly] GO:0051764[actin crosslink formation] GO:0071346[cellular response to interferon-gamma] GO:0071672[negative regulation of smooth muscle cell chemotaxis] GO:0071673[positive regulation of smooth muscle cell chemotaxis] GO:0071677[positive regulation of mononuclear cell migration] GO:0090026[positive regulation of monocyte chemotaxis] GO:0090271[positive regulation of fibroblast growth factor production] GO:0097178[ruffle assembly] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:2000406[positive regulation of T cell migration]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726[ruffle] GO:0001774[microglial cell activation] GO:0001891[phagocytic cup] GO:0001934[positive regulation of protein phosphorylation] GO:0003674[molecular_function] GO:0003779[actin binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0006911[phagocytosis, engulfment] GO:0006954[inflammatory response] GO:0008284[positive regulation of cell population proliferation] GO:0010468[regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0014739[positive regulation of muscle hyperplasia] GO:0016020[membrane] GO:0016601[Rac protein signal transduction] GO:0021549[cerebellum development] GO:0030027[lamellipodium] GO:0030041[actin filament polymerization] GO:0030046[parallel actin filament bundle assembly] GO:0030335[positive regulation of cell migration] GO:0031668[cellular response to extracellular stimulus] GO:0032587[ruffle membrane] GO:0032722[positive regulation of chemokine production] GO:0032755[positive regulation of interleukin-6 production] GO:0032870[cellular response to hormone stimulus] GO:0034097[response to cytokine] GO:0034599[cellular response to oxidative stress] GO:0042102[positive regulation of T cell proliferation] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043204[perikaryon] GO:0045429[positive regulation of nitric oxide biosynthetic process] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0048662[negative regulation of smooth muscle cell proliferation] GO:0048678[response to axon injury] GO:0050921[positive regulation of chemotaxis] GO:0051015[actin filament binding] GO:0051017[actin filament bundle assembly] GO:0051384[response to glucocorticoid] GO:0051602[response to electrical stimulus] GO:0051764[actin crosslink formation] GO:0071315[cellular response to morphine] GO:0071346[cellular response to interferon-gamma] GO:0071447[cellular response to hydroperoxide] GO:0071672[negative regulation of smooth muscle cell chemotaxis] GO:0071673[positive regulation of smooth muscle cell chemotaxis] GO:0071677[positive regulation of mononuclear cell migration] GO:0090026[positive regulation of monocyte chemotaxis] GO:0090271[positive regulation of fibroblast growth factor production] GO:0097178[ruffle assembly] GO:0097386[glial cell projection] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:2000406[positive regulation of T cell migration]
The Human Protein Atlas project is funded
