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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins Ribosomal proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q35.3
Chromosome location (bp)
181236897 - 181248096
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression 1. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits 2. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane 3. Promotes migration of breast carcinoma cells by binding to and activating RHOA 4. Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, Ribonucleoprotein, Ribosomal protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Enables several functions, including cyclin binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of hydrolase activity; regulation of cellular protein metabolic process; and regulation of signal transduction. Located in several cellular components, including midbody; perinuclear region of cytoplasm; and phagocytic cup. Part of IRE1-RACK1-PP2A complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
H0Y8W2 [Direct mapping] Receptor of-activated protein C kinase 1
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
P63244 [Direct mapping] Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed
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E9KL35 [Target identity:100%; Query identity:100%] Epididymis tissue sperm binding protein Li 3a
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Transporters Accessory Factors Involved in Transport Ribosomal proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001891[phagocytic cup] GO:0001934[positive regulation of protein phosphorylation] GO:0002181[cytoplasmic translation] GO:0003723[RNA binding] GO:0005080[protein kinase C binding] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005840[ribosome] GO:0005886[plasma membrane] GO:0006412[translation] GO:0006417[regulation of translation] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007049[cell cycle] GO:0007369[gastrulation] GO:0008200[ion channel inhibitor activity] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010629[negative regulation of gene expression] GO:0015935[small ribosomal subunit] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0017148[negative regulation of translation] GO:0019899[enzyme binding] GO:0019903[protein phosphatase binding] GO:0022627[cytosolic small ribosomal subunit] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030292[protein tyrosine kinase inhibitor activity] GO:0030308[negative regulation of cell growth] GO:0030332[cyclin binding] GO:0030335[positive regulation of cell migration] GO:0030425[dendrite] GO:0030496[midbody] GO:0030971[receptor tyrosine kinase binding] GO:0031334[positive regulation of protein-containing complex assembly] GO:0032091[negative regulation of protein binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032880[regulation of protein localization] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0035591[signaling adaptor activity] GO:0042169[SH2 domain binding] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0042998[positive regulation of Golgi to plasma membrane protein transport] GO:0043005[neuron projection] GO:0043022[ribosome binding] GO:0043025[neuronal cell body] GO:0043065[positive regulation of apoptotic process] GO:0043204[perikaryon] GO:0043473[pigmentation] GO:0043547[positive regulation of GTPase activity] GO:0044297[cell body] GO:0045182[translation regulator activity] GO:0045296[cadherin binding] GO:0045879[negative regulation of smoothened signaling pathway] GO:0048471[perinuclear region of cytoplasm] GO:0048511[rhythmic process] GO:0050765[negative regulation of phagocytosis] GO:0051302[regulation of cell division] GO:0051343[positive regulation of cyclic-nucleotide phosphodiesterase activity] GO:0051434[BH3 domain binding] GO:0051726[regulation of cell cycle] GO:0051898[negative regulation of protein kinase B signaling] GO:0051901[positive regulation of mitochondrial depolarization] GO:0060090[molecular adaptor activity] GO:0061099[negative regulation of protein tyrosine kinase activity] GO:0070062[extracellular exosome] GO:0071333[cellular response to glucose stimulus] GO:0071363[cellular response to growth factor stimulus] GO:0072344[rescue of stalled ribosome] GO:1900102[negative regulation of endoplasmic reticulum unfolded protein response] GO:1903208[negative regulation of hydrogen peroxide-induced neuron death] GO:1990630[IRE1-RACK1-PP2A complex] GO:1990904[ribonucleoprotein complex] GO:2000114[regulation of establishment of cell polarity] GO:2000543[positive regulation of gastrulation] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
