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TSSK1B
HPA
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  • TSSK1B
PROTEIN SUMMARY GENE INFORMATION RNA DATA ANTIBODY DATA
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

TSSK1B
Synonyms FKSG81, SPOGA4, STK22D, TSSK1
Gene descriptioni

Full gene name according to HGNC.

Testis specific serine kinase 1B
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Enzymes
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 5
Cytoband q22.2
Chromosome location (bp) 113432553 - 113434989
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

1
Ensembl ENSG00000212122 (version 109)
Entrez gene 83942
HGNC HGNC:14968
UniProt Q9BXA7 (UniProt - Evidence at protein level)
neXtProt NX_Q9BXA7
GeneCards TSSK1B
Antibodypedia TSSK1B antibodies


PROTEIN FUNCTION
Protein function (UniProt)i

Useful information about the protein provided by UniProt.

Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.... show less
Molecular function (UniProt)i

Keywords assigned by UniProt to proteins due to their particular molecular function.

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological process (UniProt)i

Keywords assigned by UniProt to proteins because they are involved in a particular biological process.

Differentiation, Spermatogenesis
Ligand (UniProt)i

Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding
Gene summary (Entrez)i

Useful information about the gene from Entrez

TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004).[supplied by OMIM, Mar 2008]... show less
PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
TSSK1B-201
ENSP00000375081
ENST00000390666
Q9BXA7
[Direct mapping] Testis-specific serine/threonine-protein kinase 1
Show all
A0ZT98
[Target identity:100%; Query identity:100%] Testis tissue sperm-binding protein Li 55e; Testis-specific serine kinase 1; cDNA FLJ16575 fis, clone TESTI2004706, highly similar to Testis-specific serine/threonine-protein kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001669 [acrosomal vesicle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005929 [cilium]
GO:0006468 [protein phosphorylation]
GO:0007283 [spermatogenesis]
GO:0007286 [spermatid development]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030154 [cell differentiation]
GO:0031410 [cytoplasmic vesicle]
GO:0031514 [motile cilium]
GO:0035556 [intracellular signal transduction]
GO:0042995 [cell projection]
GO:0044877 [protein-containing complex binding]
GO:0046872 [metal ion binding]
GO:0106310 [protein serine kinase activity]
Show all
367 aa
41.6 kDa
No 1

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