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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes FDA approved drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q13.1
Chromosome location (bp)
38290691 - 38318084
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling 1,2. Phosphorylates DVL1 3. Phosphorylates DVL2 4. Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock 5. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation 6,7. Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation 8....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Biological rhythms
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases CK1 Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0003723[RNA binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006468[protein phosphorylation] GO:0006897[endocytosis] GO:0007165[signal transduction] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0032091[negative regulation of protein binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032880[regulation of protein localization] GO:0032922[circadian regulation of gene expression] GO:0042752[regulation of circadian rhythm] GO:0048511[rhythmic process] GO:0060070[canonical Wnt signaling pathway] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0106310[protein serine kinase activity] GO:1905426[positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation] GO:2000052[positive regulation of non-canonical Wnt signaling pathway]
Enzymes ENZYME proteins Transferases Kinases CK1 Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0003723[RNA binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006468[protein phosphorylation] GO:0006897[endocytosis] GO:0007165[signal transduction] GO:0008104[protein localization] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0030177[positive regulation of Wnt signaling pathway] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030426[growth cone] GO:0032091[negative regulation of protein binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032880[regulation of protein localization] GO:0032922[circadian regulation of gene expression] GO:0042752[regulation of circadian rhythm] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0048511[rhythmic process] GO:0048512[circadian behavior] GO:0060070[canonical Wnt signaling pathway] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0106310[protein serine kinase activity] GO:1902004[positive regulation of amyloid-beta formation] GO:1905426[positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990904[ribonucleoprotein complex] GO:2000052[positive regulation of non-canonical Wnt signaling pathway]
Enzymes ENZYME proteins Transferases Kinases CK1 Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0003723[RNA binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006468[protein phosphorylation] GO:0006897[endocytosis] GO:0007165[signal transduction] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0032091[negative regulation of protein binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032880[regulation of protein localization] GO:0032922[circadian regulation of gene expression] GO:0042752[regulation of circadian rhythm] GO:0048511[rhythmic process] GO:0060070[canonical Wnt signaling pathway] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0106310[protein serine kinase activity] GO:1905426[positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation] GO:2000052[positive regulation of non-canonical Wnt signaling pathway]
B0QY35 [Direct mapping] Casein kinase I isoform epsilon
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MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
B0QY34 [Direct mapping] Casein kinase I isoform epsilon
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MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
B0QY36 [Direct mapping] Casein kinase I isoform epsilon
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MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
H0Y645 [Direct mapping] Casein kinase I isoform epsilon
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
