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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
p11.4
Chromosome location (bp)
41333348 - 41364472
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Multifunctional ATP-dependent RNA helicase 1,2,3. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity 4. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs 5,6. Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA 7. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation 8,9. Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity 10,11. CDKN1A up-regulation may be cell-type specific 12. Binds CDH1/E-cadherin promoter and represses its transcription 13. Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis 14. May positively regulate TP53 transcription 15. Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) 16,17. Involved in the regulation of translation initiation 18,19,20. Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) 21,22. This function depends on helicase activity 23,24. Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning 25. Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety 26. Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process 27. Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle 28. May activate TP53 translation 29. Required for endoplasmic reticulum stress-induced ATF4 mRNA translation 30. Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E 31,32. Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E 33. Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) 34,35,36. Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection 37,38. Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 39,40,41,42,43. Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation 44. Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 45. Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling 46. Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm 47. May also bind IFNB promoter; the function is independent of IRF3 48. Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells 49. Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation 50. Cleavage by caspases may inactivate DDX3X and relieve the inhibition 51. Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant 52,53. ATPase and casein kinase-activating functions are mutually exclusive 54. May be involved in mitotic chromosome segregation 55....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Helicase, Hydrolase, RNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0002376[immune system process] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003678[DNA helicase activity] GO:0003723[RNA binding] GO:0003724[RNA helicase activity] GO:0003729[mRNA binding] GO:0003924[GTPase activity] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005852[eukaryotic translation initiation factor 3 complex] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006413[translational initiation] GO:0006417[regulation of translation] GO:0006915[apoptotic process] GO:0007059[chromosome segregation] GO:0007276[gamete generation] GO:0008134[transcription factor binding] GO:0008143[poly(A) binding] GO:0008190[eukaryotic initiation factor 4E binding] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0009615[response to virus] GO:0010494[cytoplasmic stress granule] GO:0010501[RNA secondary structure unwinding] GO:0010628[positive regulation of gene expression] GO:0016020[membrane] GO:0016055[Wnt signaling pathway] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0017111[ribonucleoside triphosphate phosphatase activity] GO:0017148[negative regulation of translation] GO:0022627[cytosolic small ribosomal subunit] GO:0030027[lamellipodium] GO:0030154[cell differentiation] GO:0030307[positive regulation of cell growth] GO:0030308[negative regulation of cell growth] GO:0031252[cell leading edge] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031369[translation initiation factor binding] GO:0031954[positive regulation of protein autophosphorylation] GO:0032508[DNA duplex unwinding] GO:0032727[positive regulation of interferon-alpha production] GO:0032728[positive regulation of interferon-beta production] GO:0033592[RNA strand annealing activity] GO:0034063[stress granule assembly] GO:0034157[positive regulation of toll-like receptor 7 signaling pathway] GO:0034161[positive regulation of toll-like receptor 8 signaling pathway] GO:0034774[secretory granule lumen] GO:0035556[intracellular signal transduction] GO:0035613[RNA stem-loop binding] GO:0036493[positive regulation of translation in response to endoplasmic reticulum stress] GO:0042254[ribosome biogenesis] GO:0042256[mature ribosome assembly] GO:0042995[cell projection] GO:0043015[gamma-tubulin binding] GO:0043024[ribosomal small subunit binding] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043186[P granule] GO:0043273[CTPase activity] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043539[protein serine/threonine kinase activator activity] GO:0045070[positive regulation of viral genome replication] GO:0045087[innate immune response] GO:0045296[cadherin binding] GO:0045727[positive regulation of translation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045948[positive regulation of translational initiation] GO:0048027[mRNA 5'-UTR binding] GO:0055088[lipid homeostasis] GO:0061702[inflammasome complex] GO:0070062[extracellular exosome] GO:0071243[cellular response to arsenic-containing substance] GO:0071470[cellular response to osmotic stress] GO:0071651[positive regulation of chemokine (C-C motif) ligand 5 production] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0072559[NLRP3 inflammasome complex] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0097193[intrinsic apoptotic signaling pathway] GO:0098586[cellular response to virus] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900227[positive regulation of NLRP3 inflammasome complex assembly] GO:1901223[negative regulation of NIK/NF-kappaB signaling] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1901985[positive regulation of protein acetylation] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902523[positive regulation of protein K63-linked ubiquitination] GO:1903608[protein localization to cytoplasmic stress granule] GO:1904813[ficolin-1-rich granule lumen] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0002376[immune system process] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003678[DNA helicase activity] GO:0003723[RNA binding] GO:0003724[RNA helicase activity] GO:0003729[mRNA binding] GO:0003924[GTPase activity] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005852[eukaryotic translation initiation factor 3 complex] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006413[translational initiation] GO:0006417[regulation of translation] GO:0006915[apoptotic process] GO:0007059[chromosome segregation] GO:0007276[gamete generation] GO:0008134[transcription factor binding] GO:0008143[poly(A) binding] GO:0008190[eukaryotic initiation factor 4E binding] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0009615[response to virus] GO:0010494[cytoplasmic stress granule] GO:0010501[RNA secondary structure unwinding] GO:0010628[positive regulation of gene expression] GO:0016020[membrane] GO:0016055[Wnt signaling pathway] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0017111[ribonucleoside triphosphate phosphatase activity] GO:0017148[negative regulation of translation] GO:0022627[cytosolic small ribosomal subunit] GO:0030027[lamellipodium] GO:0030154[cell differentiation] GO:0030307[positive regulation of cell growth] GO:0030308[negative regulation of cell growth] GO:0031252[cell leading edge] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031369[translation initiation factor binding] GO:0031954[positive regulation of protein autophosphorylation] GO:0032508[DNA duplex unwinding] GO:0032727[positive regulation of interferon-alpha production] GO:0032728[positive regulation of interferon-beta production] GO:0033592[RNA strand annealing activity] GO:0034063[stress granule assembly] GO:0034157[positive regulation of toll-like receptor 7 signaling pathway] GO:0034161[positive regulation of toll-like receptor 8 signaling pathway] GO:0034774[secretory granule lumen] GO:0035556[intracellular signal transduction] GO:0035613[RNA stem-loop binding] GO:0036493[positive regulation of translation in response to endoplasmic reticulum stress] GO:0042254[ribosome biogenesis] GO:0042256[mature ribosome assembly] GO:0042995[cell projection] GO:0043015[gamma-tubulin binding] GO:0043024[ribosomal small subunit binding] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043186[P granule] GO:0043273[CTPase activity] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043539[protein serine/threonine kinase activator activity] GO:0045070[positive regulation of viral genome replication] GO:0045087[innate immune response] GO:0045296[cadherin binding] GO:0045727[positive regulation of translation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045948[positive regulation of translational initiation] GO:0048027[mRNA 5'-UTR binding] GO:0055088[lipid homeostasis] GO:0061702[inflammasome complex] GO:0070062[extracellular exosome] GO:0071243[cellular response to arsenic-containing substance] GO:0071470[cellular response to osmotic stress] GO:0071651[positive regulation of chemokine (C-C motif) ligand 5 production] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0072559[NLRP3 inflammasome complex] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0097193[intrinsic apoptotic signaling pathway] GO:0098586[cellular response to virus] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900227[positive regulation of NLRP3 inflammasome complex assembly] GO:1901223[negative regulation of NIK/NF-kappaB signaling] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1901985[positive regulation of protein acetylation] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902523[positive regulation of protein K63-linked ubiquitination] GO:1903608[protein localization to cytoplasmic stress granule] GO:1904813[ficolin-1-rich granule lumen] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0002376[immune system process] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003678[DNA helicase activity] GO:0003723[RNA binding] GO:0003724[RNA helicase activity] GO:0003729[mRNA binding] GO:0003924[GTPase activity] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005852[eukaryotic translation initiation factor 3 complex] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006413[translational initiation] GO:0006417[regulation of translation] GO:0006915[apoptotic process] GO:0007059[chromosome segregation] GO:0007276[gamete generation] GO:0008134[transcription factor binding] GO:0008143[poly(A) binding] GO:0008190[eukaryotic initiation factor 4E binding] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0009615[response to virus] GO:0010494[cytoplasmic stress granule] GO:0010501[RNA secondary structure unwinding] GO:0010628[positive regulation of gene expression] GO:0016020[membrane] GO:0016055[Wnt signaling pathway] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0017111[ribonucleoside triphosphate phosphatase activity] GO:0017148[negative regulation of translation] GO:0022627[cytosolic small ribosomal subunit] GO:0030027[lamellipodium] GO:0030154[cell differentiation] GO:0030307[positive regulation of cell growth] GO:0030308[negative regulation of cell growth] GO:0031053[primary miRNA processing] GO:0031252[cell leading edge] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031369[translation initiation factor binding] GO:0031954[positive regulation of protein autophosphorylation] GO:0032508[DNA duplex unwinding] GO:0032727[positive regulation of interferon-alpha production] GO:0032728[positive regulation of interferon-beta production] GO:0033592[RNA strand annealing activity] GO:0034063[stress granule assembly] GO:0034157[positive regulation of toll-like receptor 7 signaling pathway] GO:0034161[positive regulation of toll-like receptor 8 signaling pathway] GO:0034774[secretory granule lumen] GO:0035556[intracellular signal transduction] GO:0035613[RNA stem-loop binding] GO:0036493[positive regulation of translation in response to endoplasmic reticulum stress] GO:0042254[ribosome biogenesis] GO:0042256[mature ribosome assembly] GO:0042995[cell projection] GO:0043015[gamma-tubulin binding] GO:0043024[ribosomal small subunit binding] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043186[P granule] GO:0043273[CTPase activity] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043539[protein serine/threonine kinase activator activity] GO:0045070[positive regulation of viral genome replication] GO:0045087[innate immune response] GO:0045296[cadherin binding] GO:0045727[positive regulation of translation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045948[positive regulation of translational initiation] GO:0048027[mRNA 5'-UTR binding] GO:0055088[lipid homeostasis] GO:0061702[inflammasome complex] GO:0070062[extracellular exosome] GO:0070878[primary miRNA binding] GO:0071243[cellular response to arsenic-containing substance] GO:0071470[cellular response to osmotic stress] GO:0071651[positive regulation of chemokine (C-C motif) ligand 5 production] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0072559[NLRP3 inflammasome complex] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0097193[intrinsic apoptotic signaling pathway] GO:0098586[cellular response to virus] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900227[positive regulation of NLRP3 inflammasome complex assembly] GO:1901223[negative regulation of NIK/NF-kappaB signaling] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1901985[positive regulation of protein acetylation] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902523[positive regulation of protein K63-linked ubiquitination] GO:1903608[protein localization to cytoplasmic stress granule] GO:1904813[ficolin-1-rich granule lumen] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
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