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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Ubiquitin A-52 residue ribosomal protein fusion product 1
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Ribosomal proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.11
Chromosome location (bp)
18571730 - 18577550
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
[Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Ribonucleoprotein, Ribosomal protein
Gene summary (Entrez)i
Useful information about the gene from Entrez
Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P62987 [Direct mapping] Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40
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Q3MIH3 [Target identity:100%; Query identity:100%] Ubiquitin-60S ribosomal protein L40
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Ribosomal proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P62987 [Direct mapping] Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40
Show all
Q3MIH3 [Target identity:100%; Query identity:100%] Ubiquitin-60S ribosomal protein L40
Show all
Ribosomal proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P62987 [Direct mapping] Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40
Show all
Q3MIH3 [Target identity:100%; Query identity:100%] Ubiquitin-60S ribosomal protein L40
Show all
Ribosomal proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P62987 [Direct mapping] Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40
Show all
Q3MIH3 [Target identity:100%; Query identity:100%] Ubiquitin-60S ribosomal protein L40
Show all
Ribosomal proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
M0R2S1 [Direct mapping] Ubiquitin-60S ribosomal protein L40
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
P62987 [Direct mapping] Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40
Show all
Q3MIH3 [Target identity:100%; Query identity:100%] Ubiquitin-60S ribosomal protein L40
Show all
Ribosomal proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P62987 [Direct mapping] Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40
Show all
Q3MIH3 [Target identity:100%; Query identity:100%] Ubiquitin-60S ribosomal protein L40
Show all
Ribosomal proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P62987 [Direct mapping] Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40
Show all
Q3MIH3 [Target identity:100%; Query identity:100%] Ubiquitin-60S ribosomal protein L40
Show all
Ribosomal proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P62987 [Direct mapping] Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40
Show all
Q3MIH3 [Target identity:100%; Query identity:100%] Ubiquitin-60S ribosomal protein L40
Show all
Ribosomal proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P62987 [Direct mapping] Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40
Show all
Q3MIH3 [Target identity:100%; Query identity:100%] Ubiquitin-60S ribosomal protein L40
Show all
Ribosomal proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P62987 [Direct mapping] Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40
Show all
Q3MIH3 [Target identity:100%; Query identity:100%] Ubiquitin-60S ribosomal protein L40
Show all
Ribosomal proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
