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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.32
Chromosome location (bp)
33299694 - 33314284
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading)....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000139[Golgi membrane] GO:0002397[MHC class I protein complex assembly] GO:0002398[MHC class Ib protein complex assembly] GO:0002502[peptide antigen assembly with MHC class I protein complex] GO:0003823[antigen binding] GO:0005515[protein binding] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0006890[retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum] GO:0006955[immune response] GO:0010468[regulation of gene expression] GO:0015433[ABC-type peptide antigen transporter activity] GO:0015833[peptide transport] GO:0016020[membrane] GO:0019885[antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0030670[phagocytic vesicle membrane] GO:0033116[endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0042288[MHC class I protein binding] GO:0042605[peptide antigen binding] GO:0042824[MHC class I peptide loading complex] GO:0046978[TAP1 binding] GO:0046979[TAP2 binding] GO:0050776[regulation of immune response] GO:0050823[peptide antigen stabilization] GO:0051082[unfolded protein binding] GO:0061635[regulation of protein complex stability] GO:0061779[Tapasin-ERp57 complex] GO:0062061[TAP complex binding] GO:0065003[protein-containing complex assembly] GO:0098553[lumenal side of endoplasmic reticulum membrane]
A0A024RCT1 [Target identity:100%; Query identity:100%] TAP binding protein (Tapasin), isoform CRA_c; TAPBP
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Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000139[Golgi membrane] GO:0002397[MHC class I protein complex assembly] GO:0002398[MHC class Ib protein complex assembly] GO:0002502[peptide antigen assembly with MHC class I protein complex] GO:0003823[antigen binding] GO:0005515[protein binding] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0006890[retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum] GO:0006955[immune response] GO:0010468[regulation of gene expression] GO:0015433[ABC-type peptide antigen transporter activity] GO:0015833[peptide transport] GO:0016020[membrane] GO:0019885[antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0030670[phagocytic vesicle membrane] GO:0033116[endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0042288[MHC class I protein binding] GO:0042605[peptide antigen binding] GO:0042824[MHC class I peptide loading complex] GO:0046978[TAP1 binding] GO:0046979[TAP2 binding] GO:0050776[regulation of immune response] GO:0050823[peptide antigen stabilization] GO:0051082[unfolded protein binding] GO:0061635[regulation of protein complex stability] GO:0061779[Tapasin-ERp57 complex] GO:0062061[TAP complex binding] GO:0065003[protein-containing complex assembly] GO:0098553[lumenal side of endoplasmic reticulum membrane]
Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000139[Golgi membrane] GO:0002397[MHC class I protein complex assembly] GO:0002398[MHC class Ib protein complex assembly] GO:0002502[peptide antigen assembly with MHC class I protein complex] GO:0003823[antigen binding] GO:0005515[protein binding] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0006890[retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum] GO:0006955[immune response] GO:0010468[regulation of gene expression] GO:0015433[ABC-type peptide antigen transporter activity] GO:0015833[peptide transport] GO:0016020[membrane] GO:0019885[antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0030670[phagocytic vesicle membrane] GO:0033116[endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0042288[MHC class I protein binding] GO:0042605[peptide antigen binding] GO:0042824[MHC class I peptide loading complex] GO:0046978[TAP1 binding] GO:0046979[TAP2 binding] GO:0050776[regulation of immune response] GO:0050823[peptide antigen stabilization] GO:0051082[unfolded protein binding] GO:0061635[regulation of protein complex stability] GO:0061779[Tapasin-ERp57 complex] GO:0062061[TAP complex binding] GO:0065003[protein-containing complex assembly] GO:0098553[lumenal side of endoplasmic reticulum membrane]
The Human Protein Atlas project is funded
