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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.33
Chromosome location (bp)
31353872 - 31367067
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells 1,2,3,4. May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity 5,6. Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells 7,8,9. Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome 10. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 11,12....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P01889 [Direct mapping] HLA class I histocompatibility antigen, B alpha chain
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E5FQ95 [Target identity:100%; Query identity:100%] HLA class I histocompatibility antigen; HLA class I histocompatibility antigen B alpha chain; MHC class I antigen; MHC class I protein; MHC class I protein (HLA-B)
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes Disease related genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Musculoskeletal diseases Skeletal diseases Other musculoskeletal diseases Respiratory diseases Tracheobronchial diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000139[Golgi membrane] GO:0001916[positive regulation of T cell mediated cytotoxicity] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0002474[antigen processing and presentation of peptide antigen via MHC class I] GO:0002486[antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent] GO:0002667[regulation of T cell anergy] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006952[defense response] GO:0006955[immune response] GO:0009986[cell surface] GO:0012507[ER to Golgi transport vesicle membrane] GO:0016020[membrane] GO:0016045[detection of bacterium] GO:0019882[antigen processing and presentation] GO:0030667[secretory granule membrane] GO:0030670[phagocytic vesicle membrane] GO:0031901[early endosome membrane] GO:0032655[regulation of interleukin-12 production] GO:0032675[regulation of interleukin-6 production] GO:0042270[protection from natural killer cell mediated cytotoxicity] GO:0042605[peptide antigen binding] GO:0042612[MHC class I protein complex] GO:0045087[innate immune response] GO:0046977[TAP binding] GO:0051087[chaperone binding] GO:0055038[recycling endosome membrane] GO:0070062[extracellular exosome] GO:0098553[lumenal side of endoplasmic reticulum membrane] GO:2001198[regulation of dendritic cell differentiation]
E5FQ95 [Target identity:100%; Query identity:100%] HLA class I histocompatibility antigen; HLA class I histocompatibility antigen B alpha chain; MHC class I antigen; MHC class I protein; MHC class I protein (HLA-B)
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Musculoskeletal diseases Skeletal diseases Other musculoskeletal diseases Respiratory diseases Tracheobronchial diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
E5FQ95 [Target identity:100%; Query identity:100%] HLA class I histocompatibility antigen; HLA class I histocompatibility antigen B alpha chain; MHC class I antigen; MHC class I protein; MHC class I protein (HLA-B)
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Musculoskeletal diseases Skeletal diseases Other musculoskeletal diseases Respiratory diseases Tracheobronchial diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
E5FQ95 [Target identity:100%; Query identity:100%] HLA class I histocompatibility antigen; HLA class I histocompatibility antigen B alpha chain; MHC class I antigen; MHC class I protein; MHC class I protein (HLA-B)
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Musculoskeletal diseases Skeletal diseases Other musculoskeletal diseases Respiratory diseases Tracheobronchial diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
E5FQ95 [Target identity:100%; Query identity:100%] HLA class I histocompatibility antigen; HLA class I histocompatibility antigen B alpha chain; MHC class I antigen; MHC class I protein; MHC class I protein (HLA-B)
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Musculoskeletal diseases Skeletal diseases Other musculoskeletal diseases Respiratory diseases Tracheobronchial diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
The Human Protein Atlas project is funded
