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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q11.22
Chromosome location (bp)
35278907 - 35284985
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm 1,2,3,4. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity 5,6,7. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC 8. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Initiation factor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Protein biosynthesis, Ribosome biogenesis
Gene summary (Entrez)i
Useful information about the gene from Entrez
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000054[ribosomal subunit export from nucleus] GO:0000460[maturation of 5.8S rRNA] GO:0000470[maturation of LSU-rRNA] GO:0003743[translation initiation factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006110[regulation of glycolytic process] GO:0006412[translation] GO:0006413[translational initiation] GO:0030687[preribosome, large subunit precursor] GO:0032868[response to insulin] GO:0035195[miRNA-mediated gene silencing] GO:0035278[miRNA-mediated gene silencing by inhibition of translation] GO:0042254[ribosome biogenesis] GO:0042256[mature ribosome assembly] GO:0042273[ribosomal large subunit biogenesis] GO:0042304[regulation of fatty acid biosynthetic process] GO:0043022[ribosome binding] GO:0043023[ribosomal large subunit binding] GO:0045652[regulation of megakaryocyte differentiation] GO:0045727[positive regulation of translation] GO:0070062[extracellular exosome] GO:1902626[assembly of large subunit precursor of preribosome] GO:2000377[regulation of reactive oxygen species metabolic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000054[ribosomal subunit export from nucleus] GO:0000460[maturation of 5.8S rRNA] GO:0000470[maturation of LSU-rRNA] GO:0003743[translation initiation factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006110[regulation of glycolytic process] GO:0006412[translation] GO:0006413[translational initiation] GO:0030687[preribosome, large subunit precursor] GO:0032868[response to insulin] GO:0035195[miRNA-mediated gene silencing] GO:0035278[miRNA-mediated gene silencing by inhibition of translation] GO:0042254[ribosome biogenesis] GO:0042256[mature ribosome assembly] GO:0042273[ribosomal large subunit biogenesis] GO:0042304[regulation of fatty acid biosynthetic process] GO:0043022[ribosome binding] GO:0043023[ribosomal large subunit binding] GO:0045652[regulation of megakaryocyte differentiation] GO:0045727[positive regulation of translation] GO:0070062[extracellular exosome] GO:1902626[assembly of large subunit precursor of preribosome] GO:2000377[regulation of reactive oxygen species metabolic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000054[ribosomal subunit export from nucleus] GO:0000460[maturation of 5.8S rRNA] GO:0000470[maturation of LSU-rRNA] GO:0003743[translation initiation factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006110[regulation of glycolytic process] GO:0006412[translation] GO:0006413[translational initiation] GO:0030687[preribosome, large subunit precursor] GO:0032868[response to insulin] GO:0035195[miRNA-mediated gene silencing] GO:0035278[miRNA-mediated gene silencing by inhibition of translation] GO:0042254[ribosome biogenesis] GO:0042256[mature ribosome assembly] GO:0042273[ribosomal large subunit biogenesis] GO:0042304[regulation of fatty acid biosynthetic process] GO:0043022[ribosome binding] GO:0043023[ribosomal large subunit binding] GO:0045652[regulation of megakaryocyte differentiation] GO:0045727[positive regulation of translation] GO:0070062[extracellular exosome] GO:1902626[assembly of large subunit precursor of preribosome] GO:2000377[regulation of reactive oxygen species metabolic process]
The Human Protein Atlas project is funded
