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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q13.13
Chromosome location (bp)
50081124 - 50115959
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'- linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production 1. UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ubl conjugation pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000151[ubiquitin ligase complex] GO:0000209[protein polyubiquitination] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006282[regulation of DNA repair] GO:0006301[postreplication repair] GO:0006355[regulation of DNA-templated transcription] GO:0030154[cell differentiation] GO:0031371[ubiquitin conjugating enzyme complex] GO:0032991[protein-containing complex] GO:0035370[UBC13-UEV1A complex] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070062[extracellular exosome] GO:0070534[protein K63-linked ubiquitination] GO:1902523[positive regulation of protein K63-linked ubiquitination] GO:1902533[positive regulation of intracellular signal transduction]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0000209[protein polyubiquitination] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006282[regulation of DNA repair] GO:0006301[postreplication repair] GO:0006355[regulation of DNA-templated transcription] GO:0030154[cell differentiation] GO:0031371[ubiquitin conjugating enzyme complex] GO:0032991[protein-containing complex] GO:0035370[UBC13-UEV1A complex] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070062[extracellular exosome] GO:0070534[protein K63-linked ubiquitination] GO:1902523[positive regulation of protein K63-linked ubiquitination] GO:1902533[positive regulation of intracellular signal transduction]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000151[ubiquitin ligase complex] GO:0000209[protein polyubiquitination] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006282[regulation of DNA repair] GO:0006301[postreplication repair] GO:0006355[regulation of DNA-templated transcription] GO:0030154[cell differentiation] GO:0031371[ubiquitin conjugating enzyme complex] GO:0032991[protein-containing complex] GO:0035370[UBC13-UEV1A complex] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070062[extracellular exosome] GO:0070534[protein K63-linked ubiquitination] GO:1902523[positive regulation of protein K63-linked ubiquitination] GO:1902533[positive regulation of intracellular signal transduction]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0000209[protein polyubiquitination] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006282[regulation of DNA repair] GO:0006301[postreplication repair] GO:0006355[regulation of DNA-templated transcription] GO:0030154[cell differentiation] GO:0031371[ubiquitin conjugating enzyme complex] GO:0032991[protein-containing complex] GO:0035370[UBC13-UEV1A complex] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070062[extracellular exosome] GO:0070534[protein K63-linked ubiquitination] GO:1902523[positive regulation of protein K63-linked ubiquitination] GO:1902533[positive regulation of intracellular signal transduction]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0000209[protein polyubiquitination] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006282[regulation of DNA repair] GO:0006301[postreplication repair] GO:0006355[regulation of DNA-templated transcription] GO:0030154[cell differentiation] GO:0031371[ubiquitin conjugating enzyme complex] GO:0032991[protein-containing complex] GO:0035370[UBC13-UEV1A complex] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070062[extracellular exosome] GO:0070534[protein K63-linked ubiquitination] GO:1902523[positive regulation of protein K63-linked ubiquitination] GO:1902533[positive regulation of intracellular signal transduction]
The Human Protein Atlas project is funded
