We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q13.2
Chromosome location (bp)
70968166 - 71025339
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Protease inhibitor, Thiol protease inhibitor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q13075 [Direct mapping] Baculoviral IAP repeat-containing protein 1
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0002221[pattern recognition receptor signaling pathway] GO:0002376[immune system process] GO:0004869[cysteine-type endopeptidase inhibitor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0007399[nervous system development] GO:0010466[negative regulation of peptidase activity] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016045[detection of bacterium] GO:0016323[basolateral plasma membrane] GO:0030414[peptidase inhibitor activity] GO:0032731[positive regulation of interleukin-1 beta production] GO:0042742[defense response to bacterium] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0045087[innate immune response] GO:0046330[positive regulation of JNK cascade] GO:0046456[icosanoid biosynthetic process] GO:0046872[metal ion binding] GO:0050729[positive regulation of inflammatory response] GO:0050896[response to stimulus] GO:0052548[regulation of endopeptidase activity] GO:0061702[inflammasome complex] GO:0070269[pyroptosis] GO:0072557[IPAF inflammasome complex] GO:0120283[protein serine/threonine kinase binding]
Q13075 [Direct mapping] Baculoviral IAP repeat-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0002221[pattern recognition receptor signaling pathway] GO:0002376[immune system process] GO:0004869[cysteine-type endopeptidase inhibitor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0007399[nervous system development] GO:0010466[negative regulation of peptidase activity] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016045[detection of bacterium] GO:0016323[basolateral plasma membrane] GO:0030414[peptidase inhibitor activity] GO:0032731[positive regulation of interleukin-1 beta production] GO:0042742[defense response to bacterium] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0045087[innate immune response] GO:0046330[positive regulation of JNK cascade] GO:0046456[icosanoid biosynthetic process] GO:0046872[metal ion binding] GO:0050729[positive regulation of inflammatory response] GO:0050896[response to stimulus] GO:0052548[regulation of endopeptidase activity] GO:0061702[inflammasome complex] GO:0070269[pyroptosis] GO:0072557[IPAF inflammasome complex] GO:0120283[protein serine/threonine kinase binding]
E7EQW0 [Direct mapping] Baculoviral IAP repeat-containing protein 1
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737[cytoplasm] GO:0006915[apoptotic process] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046872[metal ion binding] GO:0050896[response to stimulus] GO:0052548[regulation of endopeptidase activity]
H0YAX2 [Direct mapping] Baculoviral IAP repeat-containing protein 1
Show all
SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006915[apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
Q13075 [Direct mapping] Baculoviral IAP repeat-containing protein 1
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0002221[pattern recognition receptor signaling pathway] GO:0002376[immune system process] GO:0004869[cysteine-type endopeptidase inhibitor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0007399[nervous system development] GO:0010466[negative regulation of peptidase activity] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016045[detection of bacterium] GO:0016323[basolateral plasma membrane] GO:0030414[peptidase inhibitor activity] GO:0032731[positive regulation of interleukin-1 beta production] GO:0042742[defense response to bacterium] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0045087[innate immune response] GO:0046330[positive regulation of JNK cascade] GO:0046456[icosanoid biosynthetic process] GO:0046872[metal ion binding] GO:0050729[positive regulation of inflammatory response] GO:0050896[response to stimulus] GO:0052548[regulation of endopeptidase activity] GO:0061702[inflammasome complex] GO:0070269[pyroptosis] GO:0072557[IPAF inflammasome complex] GO:0120283[protein serine/threonine kinase binding]
Q13075 [Direct mapping] Baculoviral IAP repeat-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0002221[pattern recognition receptor signaling pathway] GO:0002376[immune system process] GO:0004869[cysteine-type endopeptidase inhibitor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0007399[nervous system development] GO:0010466[negative regulation of peptidase activity] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016045[detection of bacterium] GO:0016323[basolateral plasma membrane] GO:0030414[peptidase inhibitor activity] GO:0032731[positive regulation of interleukin-1 beta production] GO:0042742[defense response to bacterium] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0045087[innate immune response] GO:0046330[positive regulation of JNK cascade] GO:0046456[icosanoid biosynthetic process] GO:0046872[metal ion binding] GO:0050729[positive regulation of inflammatory response] GO:0050896[response to stimulus] GO:0052548[regulation of endopeptidase activity] GO:0061702[inflammasome complex] GO:0070269[pyroptosis] GO:0072557[IPAF inflammasome complex] GO:0120283[protein serine/threonine kinase binding]
The Human Protein Atlas project is funded
