Single cell type - RPL36A-HNRNPH2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RPL36A-HNRNPH2
Gene descriptionⁱ Full gene name according to HGNC.	RPL36A-HNRNPH2 readthrough
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Astrocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	Not detected
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at transcript level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Not detected

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

RPL36A-HNRNPH2 is part of cluster 47 Astrocytes - Unknown function with confidenceⁱ 1
196 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TMEM265	Transmembrane protein 265	0.7689	47
TOMM6	Translocase of outer mitochondrial membrane 6	0.7320	47
SPOUT1	SPOUT domain containing methyltransferase 1	0.7116	47
FAM156A	Family with sequence similarity 156 member A	0.7084	69
NPFF	Neuropeptide FF-amide peptide precursor	0.6864	47
DTNA	Dystrobrevin alpha	0.6838	47
NICN1	Nicolin 1, tubulin polyglutamylase complex subunit	0.6644	47
STPG2	Sperm tail PG-rich repeat containing 2	0.6465	51
PIRT	Phosphoinositide interacting regulator of transient receptor potential channels	0.6155	47
LGI1	Leucine rich glioma inactivated 1	0.6098	47
PRICKLE4	Prickle planar cell polarity protein 4	0.6069	47
ENSG00000283765	Novel protein	0.6057	8
NCAN	Neurocan	0.6053	47
GPC5	Glypican 5	0.6019	47
ENSG00000286112	Kynurenine aminotransferase 1	0.5980	8

IMMUNE CELLS

RPL36A-HNRNPH2 is part of cluster 18 Non-specific - Translation with confidenceⁱ 1
120 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LONP1	Lon peptidase 1, mitochondrial	1.0000	18
TAF6L	TATA-box binding protein associated factor 6 like	1.0000	18
BPHL	Biphenyl hydrolase like	0.9762	18
RABGGTB	Rab geranylgeranyltransferase subunit beta	0.9762	18
RPL15	Ribosomal protein L15	0.9762	18
RPL26	Ribosomal protein L26	0.9762	18
LCMT2	Leucine carboxyl methyltransferase 2	0.9762	18
RACK1	Receptor for activated C kinase 1	0.9524	18
MTREX	Mtr4 exosome RNA helicase	0.9524	18
DXO	Decapping exoribonuclease	0.9524	18
YRDC	YrdC N6-threonylcarbamoyltransferase domain containing	0.9524	18
RPS9	Ribosomal protein S9	0.9524	18
EEF2	Eukaryotic translation elongation factor 2	0.9524	18
RPL29	Ribosomal protein L29	0.9524	18
TMEM69	Transmembrane protein 69	0.9524	18