Single cell type - FPGT-TNNI3K - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FPGT-TNNI3K
Gene descriptionⁱ Full gene name according to HGNC.	FPGT-TNNI3K readthrough
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cardiomyocytes - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Cardiomyocytes, Oligodendrocyte precursor cells, Astrocytes, Inhibitory neurons, Excitatory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.81
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Cardiomyocytes, Oligodendrocyte precursor cells, Astrocytes, Inhibitory neurons, Excitatory neurons)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

FPGT-TNNI3K is part of cluster 68 Cardiomyocytes - Muscle contraction with confidenceⁱ 1
262 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RBM20	RNA binding motif protein 20	0.7912	68
NDUFS1	NADH:ubiquinone oxidoreductase core subunit S1	0.7397	68
LDB3	LIM domain binding 3	0.7326	68
MYOM1	Myomesin 1	0.7282	68
FBXO40	F-box protein 40	0.7207	68
HRC	Histidine rich calcium binding protein	0.7201	68
CKMT2	Creatine kinase, mitochondrial 2	0.7198	68
MYBPC3	Myosin binding protein C3	0.7172	68
TNNI3	Troponin I3, cardiac type	0.7171	68
COX7A1	Cytochrome c oxidase subunit 7A1	0.7156	68
TECRL	Trans-2,3-enoyl-CoA reductase like	0.7151	68
LRRC10	Leucine rich repeat containing 10	0.7148	68
ANKRD1	Ankyrin repeat domain 1	0.7134	68
SGCG	Sarcoglycan gamma	0.7109	68
SYNPO2L	Synaptopodin 2 like	0.7055	68

IMMUNE CELLS

FPGT-TNNI3K is part of cluster 41 Basophils - Unknown function with confidenceⁱ 0.91
293 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
JRK	Jrk helix-turn-helix protein	1.0000	41
RITA1	RBPJ interacting and tubulin associated 1	0.9762	41
SWI5	SWI5 homologous recombination repair protein	0.9762	41
LUZP1	Leucine zipper protein 1	0.9762	41
FAM227B	Family with sequence similarity 227 member B	0.9762	41
NEMF	Nuclear export mediator factor	0.9762	41
PGRMC2	Progesterone receptor membrane component 2	0.9762	41
EXTL2	Exostosin like glycosyltransferase 2	0.9762	41
TMEM168	Transmembrane protein 168	0.9762	41
NBEAL1	Neurobeachin like 1	0.9762	41
NFX1	Nuclear transcription factor, X-box binding 1	0.9762	41
FAM149B1	Family with sequence similarity 149 member B1	0.9762	41
AHI1	Abelson helper integration site 1	0.9762	41
AP4B1	Adaptor related protein complex 4 subunit beta 1	0.9762	41
CHD1L	Chromodomain helicase DNA binding protein 1 like	0.9762	41