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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q11.22
Chromosome location (bp)
46005088 - 46030623
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis 1,2. Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy 3,4. Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion 5. Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation 6. In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma 7,8. Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR 9. Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function 10. May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex 11....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of endocrine organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0003713[transcription coactivator activity] GO:0005634[nucleus] GO:0006622[protein targeting to lysosome] GO:0006879[cellular iron ion homeostasis] GO:0008584[male gonad development] GO:0009725[response to hormone] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0044754[autolysosome] GO:0045893[positive regulation of DNA-templated transcription] GO:0071391[cellular response to estrogen stimulus] GO:0071394[cellular response to testosterone stimulus]
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of endocrine organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006622[protein targeting to lysosome] GO:0006879[cellular iron ion homeostasis] GO:0008584[male gonad development] GO:0009725[response to hormone] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0044754[autolysosome] GO:0045893[positive regulation of DNA-templated transcription] GO:0071391[cellular response to estrogen stimulus] GO:0071394[cellular response to testosterone stimulus]
B4DZ85 [Direct mapping] Nuclear receptor coactivator 4; cDNA FLJ58555, highly similar to Nuclear receptor coactivator 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs
Show all
GO:0003713[transcription coactivator activity] GO:0006879[cellular iron ion homeostasis] GO:0045893[positive regulation of DNA-templated transcription]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of endocrine organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0003713[transcription coactivator activity] GO:0005634[nucleus] GO:0006622[protein targeting to lysosome] GO:0006879[cellular iron ion homeostasis] GO:0008584[male gonad development] GO:0009725[response to hormone] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0044754[autolysosome] GO:0045893[positive regulation of DNA-templated transcription] GO:0071391[cellular response to estrogen stimulus] GO:0071394[cellular response to testosterone stimulus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of endocrine organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0003713[transcription coactivator activity] GO:0005634[nucleus] GO:0006622[protein targeting to lysosome] GO:0006879[cellular iron ion homeostasis] GO:0008584[male gonad development] GO:0009725[response to hormone] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0044754[autolysosome] GO:0045893[positive regulation of DNA-templated transcription] GO:0071391[cellular response to estrogen stimulus] GO:0071394[cellular response to testosterone stimulus]
B4DF87 [Direct mapping] Nuclear receptor coactivator 4; cDNA FLJ59491, highly similar to Nuclear receptor coactivator 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs
Show all
GO:0003713[transcription coactivator activity] GO:0006879[cellular iron ion homeostasis] GO:0045893[positive regulation of DNA-templated transcription]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of endocrine organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0003713[transcription coactivator activity] GO:0005634[nucleus] GO:0006622[protein targeting to lysosome] GO:0006879[cellular iron ion homeostasis] GO:0008584[male gonad development] GO:0009725[response to hormone] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0044754[autolysosome] GO:0045893[positive regulation of DNA-templated transcription] GO:0071391[cellular response to estrogen stimulus] GO:0071394[cellular response to testosterone stimulus]
The Human Protein Atlas project is funded
