Single cell type - ENSG00000267740 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ENSG00000267740
Gene descriptionⁱ Full gene name according to HGNC.	Novel protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Squamous epithelial cells, Plasma cells, Cardiomyocytes, Basal squamous epithelial cells, Erythroid cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.92
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Single nuclei - Brain

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Squamous epithelial cells, Plasma cells, Cardiomyocytes, Basal squamous epithelial cells, Erythroid cells)

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ENSG00000267740 is part of cluster 49 Non-specific - Transcription with confidenceⁱ 1
378 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MRPS24	Mitochondrial ribosomal protein S24	0.7766	49
WBP1	WW domain binding protein 1	0.7730	49
H2BC12	H2B clustered histone 12	0.7239	77
NME2	NME/NM23 nucleoside diphosphate kinase 2	0.7118	49
PAM16	Presequence translocase associated motor 16	0.7017	49
ENSG00000256646	Novel PSMA2 and C7orf25 readthrough	0.6731	49
NDUFC2-KCTD14	NDUFC2-KCTD14 readthrough	0.6658	49
ENSG00000249209	Novel protein similar to ATP synthase delta (OSCP) subunit domain	0.6621	49
BSCL2	BSCL2 lipid droplet biogenesis associated, seipin	0.6404	77
ENSG00000267001	Novel protein	0.6375	49
NAPA	NSF attachment protein alpha	0.6266	49
CCDC142	Coiled-coil domain containing 142	0.6265	49
C11orf98	Chromosome 11 open reading frame 98	0.6170	49
SUPT4H1	SPT4 homolog, DSIF elongation factor subunit	0.6150	49
ENSG00000280571	Novel protein	0.6148	49

IMMUNE CELLS

ENSG00000267740 is part of cluster 10 Non-specific - Membrane trafficking with confidenceⁱ 0.97
408 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KIF5B	Kinesin family member 5B	1.0000	10
TM9SF1	Transmembrane 9 superfamily member 1	0.9762	10
MKKS	MKKS centrosomal shuttling protein	0.9762	10
TAX1BP3	Tax1 binding protein 3	0.9762	10
MAFG	MAF bZIP transcription factor G	0.9762	10
WDR45	WD repeat domain 45	0.9762	10
H1-0	H1.0 linker histone	0.9762	10
SEC23B	SEC23 homolog B, COPII coat complex component	0.9762	10
ADPGK	ADP dependent glucokinase	0.9524	10
ARF4	ADP ribosylation factor 4	0.9524	10
LMAN2	Lectin, mannose binding 2	0.9524	10
HSD17B4	Hydroxysteroid 17-beta dehydrogenase 4	0.9524	10
PHETA2	PH domain containing endocytic trafficking adaptor 2	0.9524	10
SETD4	SET domain containing 4	0.9524	10
ZDHHC17	Zinc finger DHHC-type palmitoyltransferase 17	0.9524	10