Single cell type - FMC1-LUC7L2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FMC1-LUC7L2
Gene descriptionⁱ Full gene name according to HGNC.	FMC1-LUC7L2 readthrough
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	Not detected
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Not detected

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

FMC1-LUC7L2 is part of cluster 31 Spermatocytes - Spermatogenesis with confidenceⁱ 1
240 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IMPA1	Inositol monophosphatase 1	0.5566	31
MT-ATP8	Mitochondrially encoded ATP synthase membrane subunit 8	0.5465	68
SNURF	SNRPN upstream open reading frame	0.5296	68
CETN3	Centrin 3	0.5176	31
ENSG00000278633		0.5175	31
ZBED5	Zinc finger BED-type containing 5	0.5174	55
TDRD15	Tudor domain containing 15	0.5085	31
SLC25A31	Solute carrier family 25 member 31	0.5007	31
SP100	SP100 nuclear antigen	0.5005	68
TPR	Translocated promoter region, nuclear basket protein	0.4998	31
LDHAL6B	Lactate dehydrogenase A like 6B	0.4933	31
SETX	Senataxin	0.4913	55
PRRG3	Proline rich and Gla domain 3	0.4867	68
MT-ND4L	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L	0.4865	68
MYL7	Myosin light chain 7	0.4820	68

IMMUNE CELLS

FMC1-LUC7L2 is part of cluster 3 Non-specific - Nuclear processes with confidenceⁱ 0.82
471 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EIF5B	Eukaryotic translation initiation factor 5B	0.9762	3
PHC3	Polyhomeotic homolog 3	0.9762	12
DNAAF10	Dynein axonemal assembly factor 10	0.9524	12
NXT1	Nuclear transport factor 2 like export factor 1	0.9524	12
FAM133B	Family with sequence similarity 133 member B	0.9524	12
POLR2M	RNA polymerase II subunit M	0.9286	3
POLR2I	RNA polymerase II subunit I	0.9286	12
NEK1	NIMA related kinase 1	0.9286	3
MCPH1	Microcephalin 1	0.9286	3
LIPT2	Lipoyl(octanoyl) transferase 2	0.9286	3
HIBCH	3-hydroxyisobutyryl-CoA hydrolase	0.9286	3
FNBP4	Formin binding protein 4	0.9048	22
CCNC	Cyclin C	0.9048	3
RPAIN	RPA interacting protein	0.9048	12
MRPL40	Mitochondrial ribosomal protein L40	0.9048	12