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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
q21
Chromosome location (bp)
106969831 - 106975627
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells 1. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity)....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
CD markers SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001666[response to hypoxia] GO:0001775[cell activation] GO:0001959[regulation of cytokine-mediated signaling pathway] GO:0002237[response to molecule of bacterial origin] GO:0002768[immune response-regulating cell surface receptor signaling pathway] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0007155[cell adhesion] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0016020[membrane] GO:0016055[Wnt signaling pathway] GO:0016477[cell migration] GO:0019901[protein kinase binding] GO:0030296[protein tyrosine kinase activator activity] GO:0030856[regulation of epithelial cell differentiation] GO:0031295[T cell costimulation] GO:0032597[B cell receptor transport into membrane raft] GO:0032600[chemokine receptor transport out of membrane raft] GO:0032913[negative regulation of transforming growth factor beta3 production] GO:0042104[positive regulation of activated T cell proliferation] GO:0042325[regulation of phosphorylation] GO:0042632[cholesterol homeostasis] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043408[regulation of MAPK cascade] GO:0043627[response to estrogen] GO:0045121[membrane raft] GO:0045730[respiratory burst] GO:0072112[podocyte differentiation] GO:0072139[glomerular parietal epithelial cell differentiation] GO:0097193[intrinsic apoptotic signaling pathway] GO:0098609[cell-cell adhesion] GO:2000768[positive regulation of nephron tubule epithelial cell differentiation]
The Human Protein Atlas project is funded
