Single cell type - ENSG00000273155 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ENSG00000273155
Gene descriptionⁱ Full gene name according to HGNC.	Novel LIPT1-MRPL30 readthrough
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Ribosome (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Distal tubular cells, Cholangiocytes, Collecting duct cells, Proximal tubular cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.79
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not detected
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at transcript level

ASSAYSⁱ

Single cell type

Single nuclei - Brain

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Distal tubular cells, Cholangiocytes, Collecting duct cells, Proximal tubular cells)

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Not detected

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ENSG00000273155 is part of cluster 64 Non-specific - Ribosome with confidenceⁱ 1
168 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RPL7	Ribosomal protein L7	0.5871	64
SNRPE	Small nuclear ribonucleoprotein polypeptide E	0.5727	64
NPM3	Nucleophosmin/nucleoplasmin 3	0.5606	64
LSM8	LSM8 homolog, U6 small nuclear RNA associated	0.5605	39
RPL26	Ribosomal protein L26	0.5569	64
RPL21	Ribosomal protein L21	0.5507	64
PET117	PET117 cytochrome c oxidase chaperone	0.5485	39
RPL31	Ribosomal protein L31	0.5443	64
COMMD6	COMM domain containing 6	0.5430	64
RPL34	Ribosomal protein L34	0.5373	64
HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.5337	64
RPL27A	Ribosomal protein L27a	0.5265	64
ZFAND1	Zinc finger AN1-type containing 1	0.5216	64
HNRNPA1L3	Heterogeneous nuclear ribonucleoprotein A1 like 3	0.5205	64
RPL23A	Ribosomal protein L23a	0.5188	64

IMMUNE CELLS

ENSG00000273155 is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 0.92
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PAN2	Poly(A) specific ribonuclease subunit PAN2	1.0000	33
MLST8	MTOR associated protein, LST8 homolog	0.9762	33
DNPH1	2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0.9762	33
TTF2	Transcription termination factor 2	0.9762	33
SEPTIN10	Septin 10	0.9524	33
VPS50	VPS50 subunit of EARP/GARPII complex	0.9524	33
USP38	Ubiquitin specific peptidase 38	0.9524	33
CENPN	Centromere protein N	0.9524	33
TMCO4	Transmembrane and coiled-coil domains 4	0.9524	33
NXF1	Nuclear RNA export factor 1	0.9524	33
MAU2	MAU2 sister chromatid cohesion factor	0.9524	33
SMC1A	Structural maintenance of chromosomes 1A	0.9524	33
CPSF1	Cleavage and polyadenylation specific factor 1	0.9524	33
GATB	Glutamyl-tRNA amidotransferase subunit B	0.9524	33
OAS2	2'-5'-oligoadenylate synthetase 2	0.9286	33