Single cell type - ENSG00000277836 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ENSG00000277836
Gene descriptionⁱ Full gene name according to HGNC.
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Plasma cells - Immunoglobulins & histones (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enriched (Plasma cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	1.00
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not detected
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (memory B-cell, naive B-cell)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at transcript level

ASSAYSⁱ

Single cell type

Single nuclei - Brain

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enriched (Plasma cells)

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Not detected

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Group enriched (memory B-cell, naive B-cell)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ENSG00000277836 is part of cluster 61 Plasma cells - Immunoglobulins & histones with confidenceⁱ 1
169 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IGHV3OR16-17	Immunoglobulin heavy variable 3/OR16-17 (non-functional)	0.9934	61
IGHV3OR16-8	Immunoglobulin heavy variable 3/OR16-8 (non-functional)	0.9932	61
IGLV3-9	Immunoglobulin lambda variable 3-9	0.9925	61
IGHV3OR16-12	Immunoglobulin heavy variable 3/OR16-12 (non-functional)	0.9919	61
IGHV2-26	Immunoglobulin heavy variable 2-26	0.9915	61
IGHV4OR15-8	Immunoglobulin heavy variable 4/OR15-8 (non-functional)	0.9915	61
IGHV3OR16-9	Immunoglobulin heavy variable 3/OR16-9 (non-functional)	0.9914	61
IGHV1OR21-1	Immunoglobulin heavy variable 1/OR21-1 (non-functional)	0.9913	61
IGLV1-36	Immunoglobulin lambda variable 1-36	0.9910	61
IGHV3OR15-7	Immunoglobulin heavy variable 3/OR15-7 (pseudogene)	0.9890	61
IGHV1OR15-9	Immunoglobulin heavy variable 1/OR15-9 (non-functional)	0.9881	61
IGHV3-35	Immunoglobulin heavy variable 3-35 (non-functional)	0.9870	61
IGKV2D-29	Immunoglobulin kappa variable 2D-29	0.9824	61
IGKV3D-11	Immunoglobulin kappa variable 3D-11	0.9803	61
IGLV2-33	Immunoglobulin lambda variable 2-33 (non-functional)	0.9789	61

IMMUNE CELLS

ENSG00000277836 is part of cluster 18 Non-specific - Translation with confidenceⁱ 0.98
120 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CR2	Complement C3d receptor 2	1.0000	18
IGKV1D-43	Immunoglobulin kappa variable 1D-43	1.0000	18
HLA-DOB	Major histocompatibility complex, class II, DO beta	1.0000	18
IGHV1-2	Immunoglobulin heavy variable 1-2	1.0000	18
IGHM	Immunoglobulin heavy constant mu	1.0000	18
GRAPL	GRB2 related adaptor protein like	1.0000	18
CLEC17A	C-type lectin domain containing 17A	1.0000	18
PKIG	CAMP-dependent protein kinase inhibitor gamma	1.0000	18
PRICKLE1	Prickle planar cell polarity protein 1	1.0000	18
MBD4	Methyl-CpG binding domain 4, DNA glycosylase	1.0000	18
LIMS2	LIM zinc finger domain containing 2	1.0000	18
PPFIBP1	PPFIA binding protein 1	1.0000	18
RALGPS2	Ral GEF with PH domain and SH3 binding motif 2	0.9762	14
SOBP	Sine oculis binding protein homolog	0.9762	18
STEAP1B	STEAP family member 1B	0.9762	34