Single cell type - ENSG00000282988 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ENSG00000282988
Gene descriptionⁱ Full gene name according to HGNC.	Novel protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Plasma cells - Immunoglobulins & histones (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Distal enterocytes, Prostatic glandular cells, Proximal enterocytes, Paneth cells, Sertoli cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.63
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (neutrophil, basophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at transcript level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Distal enterocytes, Prostatic glandular cells, Proximal enterocytes, Paneth cells, Sertoli cells)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Group enriched (neutrophil, basophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ENSG00000282988 is part of cluster 61 Plasma cells - Immunoglobulins & histones with confidenceⁱ 0.75
169 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
H2BC8	H2B clustered histone 8	0.8603	5
H4C1	H4 clustered histone 1	0.8208	61
H2BC15	H2B clustered histone 15	0.8169	61
H2BC6	H2B clustered histone 6	0.8047	61
CSKMT	Citrate synthase lysine methyltransferase	0.7764	61
OR9Q2	Olfactory receptor family 9 subfamily Q member 2	0.7617	5
H2BC26	H2B clustered histone 26	0.7271	80
H2BC10	H2B clustered histone 10	0.6849	61
TBCE	Tubulin folding cofactor E	0.6690	61
SDR42E2	Short chain dehydrogenase/reductase family 42E, member 2	0.6400	61
H2BC9	H2B clustered histone 9	0.6317	61
AMT	Aminomethyltransferase	0.6312	61
TAS2R41	Taste 2 receptor member 41	0.6286	16
H4C15	H4 clustered histone 15	0.6261	61
H3C1	H3 clustered histone 1	0.6239	80

IMMUNE CELLS

ENSG00000282988 is part of cluster 35 Neutrophils - Protein binding with confidenceⁱ 0.91
504 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF445	Zinc finger protein 445	1.0000	35
PGM5	Phosphoglucomutase 5	1.0000	35
ROCK1	Rho associated coiled-coil containing protein kinase 1	0.9762	35
RAB21	RAB21, member RAS oncogene family	0.9762	35
HAPSTR1	HUWE1 associated protein modifying stress responses	0.9762	35
APBB1IP	Amyloid beta precursor protein binding family B member 1 interacting protein	0.9524	35
GOLGA2	Golgin A2	0.9524	20
MBD6	Methyl-CpG binding domain protein 6	0.9524	35
FOXO3	Forkhead box O3	0.9524	35
SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2	0.9524	35
POLM	DNA polymerase mu	0.9286	20
CMIP	C-Maf inducing protein	0.9286	35
SKA1	Spindle and kinetochore associated complex subunit 1	0.9286	21
MKLN1	Muskelin 1	0.9048	21
ZFC3H1	Zinc finger C3H1-type containing	0.9048	35