Single cell type - TBCE - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TBCE
Gene descriptionⁱ Full gene name according to HGNC.	Tubulin folding cofactor E
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Rod photoreceptor cells, Cone photoreceptor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.55
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Single nuclei - Brain

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Rod photoreceptor cells, Cone photoreceptor cells)

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ

HPA datasetⁱ

Lineage

Expression

Alphabetical

Immune cell type specificity: Low immune cell specificity

Monaco datasetⁱ

Lineage

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TBCE is part of cluster 55 Non-specific - Transcription with confidenceⁱ 1
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
POLR2J3	RNA polymerase II subunit J3	0.6316	55
MLLT6	MLLT6, PHD finger containing	0.6230	55
NRDE2	NRDE-2, necessary for RNA interference, domain containing	0.5701	55
CPHXL2	Cytoplasmic polyadenylated homeobox like 2	0.5674	71
ANKRD52	Ankyrin repeat domain 52	0.5515	55
OR6J1	Olfactory receptor family 6 subfamily J member 1	0.5453	66
NPHP3	Nephrocystin 3	0.5433	6
SHPRH	SNF2 histone linker PHD RING helicase	0.5303	55
GTF2IRD2	GTF2I repeat domain containing 2	0.5260	6
CCDC92B	Coiled-coil domain containing 92B	0.5161	71
PILRB	Paired immunoglobin like type 2 receptor beta	0.5149	19
NOMO3	NODAL modulator 3	0.5147	55
OR4D9	Olfactory receptor family 4 subfamily D member 9	0.5147	19
TAS2R13	Taste 2 receptor member 13	0.5080	71
PCSK7	Proprotein convertase subtilisin/kexin type 7	0.5065	55

IMMUNE CELLS

TBCE is part of cluster 37 Monocytes & Neutrophils - Innate immune response with confidenceⁱ 0.98
275 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NEFH	Neurofilament heavy chain	1.0000	37
ATL3	Atlastin GTPase 3	0.9762	37
FNIP2	Folliculin interacting protein 2	0.9762	37
C3orf38	Chromosome 3 open reading frame 38	0.9762	37
CYP4F22	Cytochrome P450 family 4 subfamily F member 22	0.9762	37
CX3CR1	C-X3-C motif chemokine receptor 1	0.9762	37
SLC39A13	Solute carrier family 39 member 13	0.9762	37
PTPN13	Protein tyrosine phosphatase non-receptor type 13	0.9762	37
TPMT	Thiopurine S-methyltransferase	0.9762	37
GALE	UDP-galactose-4-epimerase	0.9762	37
CLIP4	CAP-Gly domain containing linker protein family member 4	0.9524	37
GLE1	GLE1 RNA export mediator	0.9524	37
ITGAL	Integrin subunit alpha L	0.9524	37
CDK2AP1	Cyclin dependent kinase 2 associated protein 1	0.9524	37
ICAM4	Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	0.9524	37