Single cell type - ABCF2-H2BK1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ABCF2-H2BK1
Gene descriptionⁱ Full gene name according to HGNC.	ABCF2-H2BK1 readthrough
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Smooth muscle cells - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Dendritic cells, Basal keratinocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.86
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Dendritic cells, Basal keratinocytes)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ

HPA datasetⁱ

Lineage

Expression

Alphabetical

Immune cell type specificity: Low immune cell specificity

Monaco datasetⁱ

Lineage

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ABCF2-H2BK1 is part of cluster 32 Smooth muscle cells - Muscle contraction with confidenceⁱ 1
236 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CAVIN1	Caveolae associated protein 1	0.6102	32
CRLF1	Cytokine receptor like factor 1	0.5472	32
ELN	Elastin	0.5428	32
AEBP1	AE binding protein 1	0.5417	32
APOL3	Apolipoprotein L3	0.5381	41
PTGIS	Prostaglandin I2 synthase	0.5315	53
OR3A3	Olfactory receptor family 3 subfamily A member 3	0.5305	55
PCSK7	Proprotein convertase subtilisin/kexin type 7	0.5288	55
LIMS2	LIM zinc finger domain containing 2	0.5225	32
IKZF1	IKAROS family zinc finger 1	0.5213	19
THBS2	Thrombospondin 2	0.5196	32
AIDA	Axin interactor, dorsalization associated	0.5138	32
FUT7	Fucosyltransferase 7	0.5042	28
RPL21	Ribosomal protein L21	0.5023	64
PRELP	Proline and arginine rich end leucine rich repeat protein	0.5022	32

IMMUNE CELLS

ABCF2-H2BK1 is part of cluster 5 Non-specific - Cell proliferation with confidenceⁱ 0.99
689 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFAIP3	TNF alpha induced protein 3	1.0000	5
PSMG1	Proteasome assembly chaperone 1	0.9762	9
TCTN3	Tectonic family member 3	0.9762	5
RNF139	Ring finger protein 139	0.9762	5
TTC39C	Tetratricopeptide repeat domain 39C	0.9762	5
CEP57	Centrosomal protein 57	0.9524	5
LAT	Linker for activation of T cells	0.9524	5
CCDC66	Coiled-coil domain containing 66	0.9524	5
SNAPC5	Small nuclear RNA activating complex polypeptide 5	0.9524	5
STARD5	StAR related lipid transfer domain containing 5	0.9524	5
ZNF146	Zinc finger protein 146	0.9524	5
EIF4E	Eukaryotic translation initiation factor 4E	0.9524	5
NOL11	Nucleolar protein 11	0.9524	5
PRKCQ	Protein kinase C theta	0.9524	5
CDC27	Cell division cycle 27	0.9286	5