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ENSG00000290147
HPA
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  • STRUCT & INT

  • ENSG00000290147
CANCER HEAD & NECK CANCER Show tissue menu
BREAST CANCER CARCINOID CERVICAL CANCER COLORECTAL CANCER ENDOMETRIAL CANCER GLIOMA HEAD AND NECK CANCER LIVER CANCER LUNG CANCER LYMPHOMA
MELANOMA OVARIAN CANCER PANCREATIC CANCER PROSTATE CANCER RENAL CANCER SKIN CANCER STOMACH CANCER TESTIS CANCER THYROID CANCER UROTHELIAL CANCER
HNSC TCGA PROTEIN HNSC CPTAC PROTEIN EXPRESSION
ANTIBODIES
AND
VALIDATION
Dictionary
Head and neck cancer
Human cancer
Head and neck squamous cell carcinoma
HEAD AND NECK SQUAMOUS CELL CARCINOMA (TCGA) - Interactive survival scatter ploti

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisi

Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.

  Survival analysis data not available.
HEAD AND NECK SQUAMOUS CELL CARCINOMA - Protein relative expression (CPTAC)
Number of samples 183
Samples
Sample ID Sample type nRPX
CPT0163610003 Normal N/A
CPT0162990004 Tumor N/A
CPT0199710003 Normal N/A
CPT0222180003 Tumor N/A
CPT0245600003 Tumor N/A
CPT0163530003 Tumor N/A
CPT0226250004 Tumor N/A
CPT0250310003 Tumor N/A
CPT0087820003 Tumor N/A
CPT0169730003 Tumor N/A
CPT0245010003 Tumor N/A
CPT0008630003 Tumor N/A
CPT0163020003 Normal N/A
CPT0163170003 Normal N/A
CPT0011130005 Tumor N/A
CPT0226090003 Normal N/A
CPT0194790003 Tumor N/A
CPT0226130003 Tumor N/A
CPT0163650003 Tumor N/A
CPT0094580003 Normal N/A
CPT0245130003 Tumor N/A
CPT0196060003 Normal N/A
CPT0245560003 Normal N/A
CPT0223460003 Normal N/A
C3N-04276-06 Normal N/A
CPT0163840003 Tumor N/A
CPT0177220003 Normal N/A
CPT0226450003 Normal N/A
CPT0163410003 Tumor N/A
CPT0244940004 Tumor N/A
CPT0223970003 Tumor N/A
CPT0123260003 Tumor N/A
CPT0196210003 Tumor N/A
CPT0199820003 Tumor N/A
CPT0245410003 Normal N/A
CPT0163090003 Tumor N/A
CPT0094350004 Tumor N/A
CPT0169920003 Normal N/A
CPT0184530003 Tumor N/A
CPT0194800003 Normal N/A
CPT0088430003 Normal N/A
CPT0235460003 Tumor N/A
CPT0195680003 Tumor N/A
CPT0237130004 Tumor N/A
CPT0163790003 Tumor N/A
CPT0245350003 Tumor N/A
CPT0088010003 Normal N/A
CPT0243140004 Normal N/A
CPT0244890004 Tumor N/A
CPT0190850003 Tumor N/A
CPT0024810003 Tumor N/A
CPT0245190003 Normal N/A
C3N-01859-04 Normal N/A
C3N-02693-06 Normal N/A
CPT0194250003 Tumor N/A
CPT0123280003 Normal N/A
CPT0163800003 Normal N/A
CPT0245630003 Tumor N/A
CPT0084650004 Normal N/A
CPT0226440003 Tumor N/A
CPT0237620004 Tumor N/A
C3N-04275-05 Normal N/A
CPT0194960003 Tumor N/A
CPT0222200003 Normal N/A
CPT0248330003 Tumor N/A
CPT0011320003 Normal N/A
CPT0163910003 Tumor N/A
CPT0245140003 Normal N/A
CPT0195860003 Tumor N/A
CPT0163740003 Tumor N/A
CPT0236620003 Tumor N/A
CPT0088060004 Tumor N/A
CPT0008930003 Tumor N/A
CPT0177390003 Tumor N/A
CPT0163250003 Normal N/A
CPT0094490004 Tumor N/A
CPT0229230003 Normal N/A
CPT0201860004 Normal N/A
CPT0176770003 Tumor N/A
CPT0194260003 Normal N/A
CPT0222360003 Tumor N/A
CPT0199830003 Normal N/A
CPT0245680003 Tumor N/A
CPT0162890003 Tumor N/A
CPT0087990003 Tumor N/A
CPT0190860003 Normal N/A
CPT0278700002 Normal N/A
C3N-01620-05 Normal N/A
CPT0123190003 Normal N/A
CPT0241980004 Tumor N/A
CPT0194420003 Tumor N/A
CPT0245180003 Tumor N/A
CPT0094560004 Tumor N/A
CPT0245460003 Normal N/A
CPT0226270003 Normal N/A
CPT0245500003 Tumor N/A
CPT0236640003 Normal N/A
CPT0243090003 Tumor N/A
CPT0281470002 Normal N/A
CPT0248520003 Tumor N/A
CPT0237500003 Normal N/A
CPT0008960003 Normal N/A
CPT0199880003 Tumor N/A
CPT0201830004 Tumor N/A
C3N-00295-05 Normal N/A
CPT0094280004 Tumor N/A
C3N-04279-05 Normal N/A
CPT0246540003 Tumor N/A
CPT0162940003 Tumor N/A
CPT0235910003 Tumor N/A
CPT0245730003 Tumor N/A
CPT0207870004 Tumor N/A
CPT0245300003 Tumor N/A
CPT0163240003 Tumor N/A
CPT0088410003 Tumor N/A
C3N-01758-04 Normal N/A
CPT0220620003 Normal N/A
CPT0195700003 Normal N/A
CPT0013430003 Tumor N/A
CPT0013000004 Tumor N/A
CPT0013130003 Tumor N/A
CPT0256560003 Tumor N/A
CPT0196040003 Tumor N/A
CPT0177010003 Tumor N/A
CPT0226340003 Tumor N/A
CPT0229220002 Normal N/A
CPT0163430003 Normal N/A
CPT0226400003 Normal N/A
CPT0163860003 Normal N/A
CPT0177200003 Tumor N/A
CPT0163600003 Tumor N/A
CPT0169750003 Normal N/A
CPT0236870003 Normal N/A
CPT0237480004 Tumor N/A
CPT0246670003 Tumor N/A
CPT0246590003 Tumor N/A
CPT0237640003 Normal N/A
CPT0084630009 Tumor N/A
CPT0199890003 Normal N/A
CPT0169890003 Tumor N/A
CPT0013250003 Normal N/A
CPT0236850004 Tumor N/A
CPT0011290003 Tumor N/A
CPT0169640003 Tumor N/A
CPT0242000004 Normal N/A
CPT0008520008 Tumor N/A
CPT0163340003 Tumor N/A
CPT0013210004 Tumor N/A
C3N-00857-05 Normal N/A
CPT0123180003 Tumor N/A
CPT0163160003 Tumor N/A
CPT0245020003 Normal N/A
CPT0248350003 Normal N/A
CPT0245450003 Tumor N/A
CPT0163480003 Tumor N/A
CPT0261520003 Tumor N/A
CPT0177710003 Tumor N/A
CPT0237150003 Normal N/A
CPT0226390003 Tumor N/A
CPT0127050003 Tumor N/A
CPT0226030003 Tumor N/A
CPT0163490003 Normal N/A
CPT0229210003 Tumor N/A
CPT0094420004 Tumor N/A
CPT0246620003 Tumor N/A
CPT0245060004 Tumor N/A
CPT0245400003 Tumor N/A
CPT0220610003 Tumor N/A
CPT0245230004 Tumor N/A
CPT0013030003 Normal N/A
CPT0195880003 Normal N/A
CPT0235920003 Normal N/A
CPT0013460003 Normal N/A
CPT0223450003 Tumor N/A
CPT0169740004 Normal N/A
CPT0163720003 Normal N/A
CPT0229190003 Tumor N/A
CPT0235470002 Normal N/A
CPT0088080003 Normal N/A
CPT0095040003 Tumor N/A
CPT0199700003 Tumor N/A
CPT0245550003 Tumor N/A
CPT0226350003 Normal N/A
Show allShow less
HEAD AND NECK CANCER - Protein expressioni

A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.

Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

 

Antibody stainingi

Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.

Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.


Antibody HPA005561

Antibody HPA075056
 Staining
  High
  Medium
  Low
  Not detected
 Intensity
  Strong
  Moderate
  Weak
  Negative
 Quantity
  >75%
  75%-25%
  <25%
  None
 Location
  Nuclear
  Cytoplasmic/membranous
  Cytoplasmic/membranous,nuclear
  None
Squamous cell carcinoma, NOS
Squamous cell carcinoma, NOS
Squamous cell carcinoma, metastatic, NOS
Adenocarcinoma, NOS

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