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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q25.1
Chromosome location (bp)
149517235 - 149736714
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis 1,2. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ 3. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation 4. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation 5. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex 6. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition 7,8....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables transcription coactivator activity. Involved in several processes, including hippo signaling; positive regulation of cell differentiation; and regulation of signal transduction. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9GZV5 [Direct mapping] WW domain-containing transcription regulator protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001649[osteoblast differentiation] GO:0001894[tissue homeostasis] GO:0001933[negative regulation of protein phosphorylation] GO:0003015[heart process] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006469[negative regulation of protein kinase activity] GO:0008284[positive regulation of cell population proliferation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0017145[stem cell division] GO:0031146[SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0032835[glomerulus development] GO:0035264[multicellular organism growth] GO:0035329[hippo signaling] GO:0042803[protein homodimerization activity] GO:0045599[negative regulation of fat cell differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048762[mesenchymal cell differentiation] GO:0060271[cilium assembly] GO:0060390[regulation of SMAD protein signal transduction] GO:0060828[regulation of canonical Wnt signaling pathway] GO:0060993[kidney morphogenesis] GO:0072307[regulation of metanephric nephron tubule epithelial cell differentiation] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:1900182[positive regulation of protein localization to nucleus]
C9J588 [Direct mapping] WW domain-containing transcription regulator protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Q9GZV5 [Direct mapping] WW domain-containing transcription regulator protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001933[negative regulation of protein phosphorylation] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006469[negative regulation of protein kinase activity] GO:0008284[positive regulation of cell population proliferation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016020[membrane] GO:0016604[nuclear body] GO:0017145[stem cell division] GO:0035329[hippo signaling] GO:0045599[negative regulation of fat cell differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0060390[regulation of SMAD protein signal transduction] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:1900182[positive regulation of protein localization to nucleus]
Q9GZV5 [Direct mapping] WW domain-containing transcription regulator protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001933[negative regulation of protein phosphorylation] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006469[negative regulation of protein kinase activity] GO:0008284[positive regulation of cell population proliferation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016020[membrane] GO:0016604[nuclear body] GO:0017145[stem cell division] GO:0035329[hippo signaling] GO:0045599[negative regulation of fat cell differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0060390[regulation of SMAD protein signal transduction] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:1900182[positive regulation of protein localization to nucleus]
C9J337 [Direct mapping] WW domain-containing transcription regulator protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
C9JQS8 [Direct mapping] WW domain-containing transcription regulator protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
C9J038 [Direct mapping] WW domain-containing transcription regulator protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
C9JR84 [Direct mapping] WW domain-containing transcription regulator protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
