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PCSK1N
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  • SUMMARY

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  • BRAIN

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BRAIN PONS AND MEDULLA Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX CHOROID PLEXUS HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA
MIDBRAIN OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
PRIMARY MOUSE DATA
ANTIBODIES
AND
VALIDATION
Brain proteome
PONS AND MEDULLA - Expression summary
Mouse brain, Intensity
Medulla oblongatai

Protein expression in mouse brain using immunofluorescence is reported as mean fluorescence intensity .

62.706
Mouse brain, Intensity
Ponsi

Protein expression in mouse brain using immunofluorescence is reported as mean fluorescence intensity .

80.367
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
HPA Brain:990.9 nTPM
FANTOM5:616.4 Scaled Tags Per Million
Pig:823.9 nTPM
Mouse:18.8 nTPM
Allen mouse:13.5 Expression energy

MEDULLA OBLONGATA - Mouse brain profilei

Protein expression in mouse brain using immunofluorescence is reported as fluorescence intensity .

, antibody HPA003925
Medulla oblongata mean intensity 62.706
intensityi

Protein expression in mouse brain using immunofluorescence is reported as mean fluorescence intensity .

FRONT BACK
Nucleus of the solitary tract 38.583
Raphe magnus nucleus 11.043
Cochlear nucleus 60.281
Lateral paragigantocellular nucleus 44.081
Raphe pallidus nucleus 8.217
Facial nucleus 13.362
Hypoglossal nucleus 11.651
Ambiguus nucleus 29.752
External cuneate nucleus 18.443
Inferior olivary nucleus 26.619
Raphe obscures nucleus 25.149
Dorsal motor nucleus of vagus 18.767
Barrington's nucleus -
Koelliker-fuse nucleus -
Motor tregiminal nucleus 10.005
Parabrachial nucleus 25.472
Principle sensory trigeminal nucleus 13.636
Locus coeruleus 80.367
Pontine nucleus 14.642
Vestibular nucleus 9.468
Pontine reticular nucleus, oral 8.475
Lateral lemniscus 4.940
Superior paraolivary nucleus 21.329

PONS AND MEDULLA - HPA Brain RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

990.9
Sample id Sample description nTPM
Anterior cochlear nucleus, ventral
nTPM: 347.4
2301 Female, age 85, both hemispheres 457.9
1984 Male, age 76, both hemispheres 379.3
2188 Female, age 91, both hemispheres 280.2
2090 Male, age 80, both hemispheres 272.4
Area postrema
nTPM: 292.0
2054 Male, age 76, both hemispheres 529.7
2306 Male, age 80, both hemispheres 201.2
2799 Male, age 61, both hemispheres 145.2
Dorsal cochlear nucleus
nTPM: 460.1
2187 Female, age 91, both hemispheres 569.5
2802 Male, age 74, right hemisphere 537.8
2370 Male, age 61, both hemispheres 479.3
2058 Male, age 76, both hemispheres 435.6
2378 Male, age 80, both hemispheres 278.6
Dorsal medullary reticular nucleus
nTPM: 613.3
2088 Male, age 76, both hemispheres 704.4
2040 Female, age 85, both hemispheres 574.9
2373 Male, age 61, both hemispheres 560.7
Dorsal motor vagal complex
nTPM: 732.2
2844 Male, age 55, unknown 991.8
2643 Male, age 74, both hemispheres 950.6
2133 Female, age 91, both hemispheres 869.0
2813 Female, age 72, unknown 748.4
2000 Male, age 74, unknown 733.6
2185 Male, age 76, both hemispheres 594.7
2797 Male, age 61, both hemispheres 489.2
2807 Female, age 85, both hemispheres 480.5
Dorsal tegmental nucleus
nTPM: 571.3
2083 Male, age 80, both hemispheres 627.7
1936 Male, age 76, left hemisphere 581.6
2358 Male, age 61, both hemispheres 561.2
2326 Male, age 74, both hemispheres 514.9
Dorsolateral tegmental area
nTPM: 513.5
2141 Male, age 76, both hemispheres 746.4
2654 Male, age 80, both hemispheres 584.6
2751 Female, age 85, both hemispheres 435.4
2360 Male, age 74, both hemispheres 413.0
2337 Male, age 61, both hemispheres 387.9
Gigantocellular reticular nuclei, medullary
nTPM: 481.1
2310 Male, age 80, both hemispheres 587.7
2314 Male, age 61, both hemispheres 561.5
2022 Male, age 76, right hemisphere 551.9
2462 Male, age 74, both hemispheres 510.7
1876 Female, age 85, both hemispheres 395.0
2387 Female, age 91, both hemispheres 279.8
Gigantocellular reticular nuclei, pars
nTPM: 591.1
2336 Male, age 61, both hemispheres 747.4
2084 Female, age 85, both hemispheres 692.1
2168 Male, age 76, both hemispheres 666.3
2330 Male, age 80, both hemispheres 449.1
2706 Male, age 80, both hemispheres 400.6
Inferior olive
nTPM: 481.4
2563 Male, age 74, both hemispheres 626.4
2085 Female, age 85, both hemispheres 588.9
2628 Female, age 91, both hemispheres 466.4
2178 Male, age 61, both hemispheres 432.8
2379 Male, age 80, both hemispheres 292.2
Kolliker-Fuse nucleus
nTPM: 456.1
2163 Male, age 80, both hemispheres 629.1
2315 Male, age 76, right hemisphere 381.0
2793 Female, age 91, left hemisphere 358.2
Lateral lemniscal nuclei
nTPM: 490.6
2169 Male, age 76, both hemispheres 628.4
2746 Female, age 85, left hemisphere 510.0
2453 Male, age 74, right hemisphere 490.0
2036 Male, age 80, both hemispheres 463.4
2320 Female, age 91, left hemisphere 361.2
Lateral medullary reticular nucleus
nTPM: 480.1
2804 Female, age 91, both hemispheres 635.3
2044 Male, age 76, both hemispheres 550.7
2374 Male, age 61, both hemispheres 524.7
2190 Female, age 85, both hemispheres 472.7
2852 Male, age 80, both hemispheres 359.6
2305 Male, age 74, both hemispheres 337.5
Lateral parabrachial nucleus
nTPM: 446.5
2139 Female, age 85, right hemisphere 605.0
2790 Male, age 61, both hemispheres 565.1
2013 Male, age 80, both hemispheres 375.1
2792 Male, age 76, both hemispheres 240.9
Lateral vestibular nucleus
nTPM: 650.8
2184 Male, age 76, both hemispheres 658.3
2311 Male, age 80, both hemispheres 643.3
Locus coeruleus
nTPM: 803.0
2123 Female, age 91, both hemispheres 958.1
2720 Male, age 74, both hemispheres 919.8
2162 Male, age 80, both hemispheres 879.3
1980 Male, age 76, both hemispheres 876.4
2317 Female, age 72, unknown 825.2
2014 Male, age 55, unknown 735.5
2788 Male, age 74, unknown 427.0
Medial olivary nucleus
nTPM: 224.6
2851 Male, age 80, both hemispheres 291.3
2138 Female, age 91, both hemispheres 222.4
1962 Male, age 76, both hemispheres 217.2
1943 Male, age 61, both hemispheres 167.5
Medial parabrachial nucleus
nTPM: 598.5
2156 Male, age 61, both hemispheres 758.7
2170 Female, age 91, both hemispheres 679.5
2786 Male, age 76, both hemispheres 597.5
2854 Male, age 80, both hemispheres 523.0
2463 Female, age 85, right hemisphere 433.8
Medial periolivary nuclei
nTPM: 459.1
2171 Female, age 85, both hemispheres 763.6
2063 Male, age 76, both hemispheres 642.2
2458 Female, age 91, both hemispheres 311.5
2791 Male, age 74, right hemisphere 291.7
2081 Male, age 80, both hemispheres 286.3
Medial vestibular nucleus
nTPM: 625.6
2624 Male, age 61, both hemispheres 810.3
2134 Male, age 76, both hemispheres 673.5
2093 Male, age 80, both hemispheres 636.1
2743 Female, age 85, both hemispheres 576.0
2803 Female, age 91, both hemispheres 532.3
2801 Male, age 74, both hemispheres 525.1
Motor facial nucleus
nTPM: 517.4
2062 Male, age 76, both hemispheres 751.8
2126 Male, age 61, both hemispheres 558.0
2327 Male, age 80, both hemispheres 534.8
2697 Female, age 85, both hemispheres 483.1
2795 Female, age 91, both hemispheres 408.3
2365 Male, age 74, right hemisphere 368.5
Motor hypoglossal nucleus
nTPM: 747.5
2277 Male, age 76, both hemispheres 834.5
2182 Male, age 80, both hemispheres 748.5
2132 Female, age 85, both hemispheres 726.1
2461 Male, age 61, both hemispheres 719.6
2125 Female, age 91, both hemispheres 708.7
Motor trigeminal nucleus
nTPM: 543.8
2335 Male, age 61, both hemispheres 814.8
2309 Male, age 76, both hemispheres 586.6
2079 Male, age 80, both hemispheres 478.3
2560 Male, age 74, both hemispheres 420.0
2321 Female, age 91, both hemispheres 419.5
Nuclei of the trapezoid body
nTPM: 566.4
2735 Female, age 85, both hemispheres 719.7
1983 Male, age 76, both hemispheres 713.9
2159 Male, age 61, both hemispheres 625.9
2166 Male, age 80, both hemispheres 428.6
2368 Female, age 91, both hemispheres 344.0
Nucleus ambiguus
nTPM: 990.9
2096 Female, age 85, both hemispheres 1556.9
2071 Male, age 76, both hemispheres 424.9
Nucleus cuneatus
nTPM: 493.2
2562 Male, age 61, both hemispheres 756.5
2131 Male, age 76, both hemispheres 711.1
2564 Male, age 74, both hemispheres 619.8
2100 Male, age 76, both hemispheres 568.1
2805 Female, age 91, both hemispheres 533.2
2381 Male, age 80, both hemispheres 408.7
2376 Male, age 61, both hemispheres 386.8
2808 Female, age 85, both hemispheres 271.3
2380 Male, age 80, both hemispheres 183.4
Nucleus gracilis
nTPM: 328.8
2627 Male, age 74, both hemispheres 427.0
2299 Female, age 85, both hemispheres 336.7
2382 Male, age 80, both hemispheres 222.6
Nucleus raphe magnus
nTPM: 585.6
2172 Female, age 85, both hemispheres 800.9
2160 Male, age 61, both hemispheres 786.6
2455 Male, age 74, both hemispheres 566.6
2051 Male, age 76, both hemispheres 534.2
2328 Male, age 80, both hemispheres 518.8
2459 Female, age 91, both hemispheres 306.7
Nucleus raphe obscurus
nTPM: 379.8
2800 Male, age 61, midline 472.1
2845 Female, age 85, midline 416.0
2142 Male, age 76, midline 251.3
Nucleus raphe pallidus
nTPM: 361.5
2183 Male, age 80, midline 629.6
1924 Male, age 61, midline 249.5
2145 Male, age 76, midline 205.4
Nucleus tractus solitarii
nTPM: 654.0
2307 Male, age 80, both hemispheres 866.9
2656 Male, age 76, both hemispheres 842.3
2191 Female, age 85, both hemispheres 600.2
2144 Female, age 91, right hemisphere 306.8
Paramedian reticular nucleus
nTPM: 544.2
2313 Male, age 61, both hemispheres 806.2
2057 Male, age 80, both hemispheres 578.0
2050 Female, age 85, both hemispheres 506.8
2052 Male, age 76, both hemispheres 285.8
Parvicellular reticular nuclei
nTPM: 465.9
2119 Male, age 80, both hemispheres 484.2
2558 Male, age 74, both hemispheres 478.5
2095 Male, age 76, both hemispheres 435.1
Parvicellular reticular nuclei, medullary
nTPM: 695.1
2181 Male, age 80, left hemisphere 830.1
2189 Female, age 91, both hemispheres 696.2
2091 Female, age 85, both hemispheres 558.9
Pedunculopontine tegmental nucleus
nTPM: 563.3
2334 Male, age 80, both hemispheres 684.3
1921 Female, age 85, both hemispheres 608.7
2338 Male, age 61, both hemispheres 397.0
Peritrigeminal nucleus
nTPM: 578.2
2179 Male, age 61, both hemispheres 642.6
2067 Female, age 85, both hemispheres 610.7
2136 Male, age 76, both hemispheres 481.3
Pontine nuclei
nTPM: 497.8
2787 Female, age 85, both hemispheres 891.7
1968 Male, age 76, left hemisphere 656.8
2727 Male, age 61, right hemisphere 526.8
1863 Male, age 55, unknown 515.8
2109 Female, age 72, unknown 455.6
2115 Male, age 80, left hemisphere 367.4
2454 Male, age 74, left hemisphere 289.3
2319 Female, age 91, both hemispheres 279.2
Pontine raphe nucleus
nTPM: 603.0
2853 Male, age 76, midline 738.4
2122 Female, age 85, midline 467.5
Posteroventral cochlear nucleus
nTPM: 403.5
2752 Female, age 85, both hemispheres 652.7
2070 Male, age 76, both hemispheres 587.0
2371 Male, age 61, both hemispheres 470.2
2341 Male, age 80, both hemispheres 186.6
2135 Female, age 91, both hemispheres 121.0
Prepositus hypoglossal nucleus
nTPM: 522.7
2086 Male, age 80, both hemispheres 556.8
2855 Female, age 85, right hemisphere 488.6
Principal sensory trigeminal nucleus
nTPM: 528.2
2324 Male, age 76, both hemispheres 688.9
2158 Male, age 61, both hemispheres 685.6
2008 Male, age 80, left hemisphere 461.1
2367 Female, age 91, left hemisphere 277.1
Reticular pontine nucleus, caudal
nTPM: 473.7
2332 Male, age 80, right hemisphere 612.0
2092 Male, age 76, both hemispheres 531.0
2559 Male, age 74, both hemispheres 416.8
2457 Female, age 91, both hemispheres 334.9
Reticular pontine nucleus, oral
nTPM: 412.5
2167 Male, age 76, both hemispheres 590.2
1939 Male, age 80, both hemispheres 467.1
2012 Female, age 85, both hemispheres 459.6
2366 Female, age 91, both hemispheres 275.5
2361 Male, age 74, both hemispheres 270.1
Reticulotegmental nucleus
nTPM: 611.9
2325 Male, age 76, both hemispheres 720.1
2322 Female, age 91, both hemispheres 592.4
2452 Male, age 74, both hemispheres 581.9
2333 Male, age 80, both hemispheres 553.1
Spinal trigeminal nucleus, caudal
nTPM: 665.6
2447 Male, age 76, both hemispheres 742.6
2308 Male, age 80, both hemispheres 683.3
2390 Female, age 91, both hemispheres 676.7
2642 Male, age 74, both hemispheres 661.1
2312 Male, age 61, both hemispheres 564.1
Spinal trigeminal nucleus, interpolar
nTPM: 570.5
2625 Male, age 61, both hemispheres 763.7
2033 Male, age 80, both hemispheres 605.7
2386 Female, age 85, both hemispheres 539.6
2389 Female, age 91, both hemispheres 488.5
2066 Male, age 76, right hemisphere 454.7
Spinal trigeminal nucleus, oral
nTPM: 609.1
1978 Male, age 76, both hemispheres 689.6
2164 Male, age 80, both hemispheres 605.9
2737 Female, age 85, both hemispheres 531.9
Spinal vestibular nucleus
nTPM: 647.6
2780 Male, age 80, both hemispheres 779.9
2186 Female, age 91, both hemispheres 703.8
2796 Male, age 61, both hemispheres 702.2
2748 Male, age 76, both hemispheres 620.7
2384 Male, age 74, both hemispheres 550.0
2806 Female, age 85, both hemispheres 529.0
Subcoeruleus area
nTPM: 599.4
2323 Female, age 91, left hemisphere 905.2
2451 Male, age 74, both hemispheres 701.2
1958 Male, age 80, both hemispheres 524.5
2089 Male, age 76, left hemisphere 522.3
2369 Female, age 85, left hemisphere 343.7
Superior olive
nTPM: 415.1
2329 Male, age 80, right hemisphere 485.1
1875 Female, age 85, both hemispheres 467.3
2020 Male, age 76, both hemispheres 417.7
2561 Female, age 91, both hemispheres 401.8
2364 Male, age 74, right hemisphere 303.4
Superior vestibular nucleus
nTPM: 501.3
2061 Male, age 76, both hemispheres 580.8
2015 Male, age 80, both hemispheres 558.1
2383 Male, age 74, both hemispheres 364.9
Ventral medullary reticular nucleus
nTPM: 571.9
2060 Male, age 76, both hemispheres 686.2
2372 Male, age 61, both hemispheres 457.6
Ventral periolivary nuclei
nTPM: 440.9
2165 Male, age 80, both hemispheres 616.7
2130 Female, age 85, both hemispheres 446.6
2023 Male, age 76, both hemispheres 353.2
2794 Female, age 91, left hemisphere 346.8
Ventrolateral medulla, A1-C1 cell groups
nTPM: 549.8
2741 Female, age 85, both hemispheres 644.3
2180 Male, age 61, both hemispheres 632.2
2302 Female, age 91, both hemispheres 596.7
1986 Male, age 76, both hemispheres 491.4
2118 Male, age 80, both hemispheres 384.3
Ventrolateral tegmental area, A5 NE cell group
nTPM: 459.1
2359 Male, age 61, both hemispheres 570.4
2449 Male, age 74, both hemispheres 487.0
2840 Female, age 85, both hemispheres 486.2
1959 Male, age 76, both hemispheres 470.6
2161 Male, age 80, both hemispheres 442.2
2456 Female, age 91, both hemispheres 298.4

PONS AND MEDULLA - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Max subtype Scaled Tags Per Millioni

Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

616.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Locus coeruleus
Scaled Tags Per Million: 418.5
FF:10182-103D2 60 years, female 460.9
FF:10165-103B3 76 years, female 376.1
Medulla oblongata
Scaled Tags Per Million: 347.2
FF:10038-101F2 18-64 years, mixed 540.7
FF:10155-103A2 76 years, female 259.5
FF:10174-103C3 60 years, female 241.4
Pons
Scaled Tags Per Million: 616.4
FF:10033-101E6 18-54 years, mixed 616.4

PONS AND MEDULLA - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

823.9
Pig sample Sample description nTPM
Medulla oblongata
nTPM: 628.4
Samples: 4

Max nTPM: 735.4
Min nTPM: 586.8
Sample A Female 735.4
Sample B Female 586.8
Sample C Male 602.3
Sample D Male 589.1
Pons
nTPM: 823.9
Samples: 4

Max nTPM: 891.7
Min nTPM: 757.4
Sample A Female 891.7
Sample B Female 762.4
Sample C Male 757.4
Sample D Male 884.1

PONS AND MEDULLA - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

18.8
Mouse sample Sample description nTPM
Pons and medulla
nTPM: 18.9
Samples: 4

Max nTPM: 28.0
Min nTPM: 10.3
Sample A Male 28.0
Sample B Male 14.4
Sample C Female 22.7
Sample D Female 10.3

PONS AND MEDULLA - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Max subtype Expression energyi

Max subtype Expression energy is the value for the subtype with the largest average Expression energy across the subtype samples.

13.5
Allen experiment id Experiment description Expression energy
Medulla oblongata
Expression energy: 12.3
79360249 Antisense, RP_071018_01_E06, Mouse strain C57BL/6J (56 days, male) 16.2
778 Antisense, RP_040315_01_19, Mouse strain C57BL/6J (56 days, male) 8.5
777 Antisense, RP_040315_01_19, Mouse strain C57BL/6J (56 days, male) 6.8
Pons
Expression energy: 13.5
79360249 Antisense, RP_071018_01_E06, Mouse strain C57BL/6J (56 days, male) 16.4
777 Antisense, RP_040315_01_19, Mouse strain C57BL/6J (56 days, male) 10.6
778 Antisense, RP_040315_01_19, Mouse strain C57BL/6J (56 days, male) 7.5

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