Single cell type - CHURC1-FNTB - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CHURC1-FNTB
Gene descriptionⁱ Full gene name according to HGNC.	CHURC1-FNTB readthrough
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocyte precursor - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Oligodendrocyte precursor cells, Oligodendrocytes, Astrocytes, Excitatory neurons, Microglial cells, Inhibitory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.94
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at transcript level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Oligodendrocyte precursor cells, Oligodendrocytes, Astrocytes, Excitatory neurons, Microglial cells, Inhibitory neurons)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

CHURC1-FNTB is part of cluster 76 Oligodendrocyte precursor - Unknown function with confidenceⁱ 1
210 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000286098	Novel protein	0.9043	76
SPDYE8	Speedy/RINGO cell cycle regulator family member E8	0.8346	76
XYLT1	Xylosyltransferase 1	0.7780	76
PEAK1	Pseudopodium enriched atypical kinase 1	0.7772	76
MBD5	Methyl-CpG binding domain protein 5	0.7697	76
ZNF816-ZNF321P	ZNF816-ZNF321P readthrough	0.7619	76
TNR	Tenascin R	0.7557	76
ZSWIM6	Zinc finger SWIM-type containing 6	0.7524	76
MMP16	Matrix metallopeptidase 16	0.7354	76
GRIK4	Glutamate ionotropic receptor kainate type subunit 4	0.7331	76
ADGRL3	Adhesion G protein-coupled receptor L3	0.7233	76
NRF1	Nuclear respiratory factor 1	0.7171	76
KIF13A	Kinesin family member 13A	0.7170	76
NAV2	Neuron navigator 2	0.7168	76
DSCAM	DS cell adhesion molecule	0.7160	76

IMMUNE CELLS

CHURC1-FNTB is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 0.9
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ADAMTSL5	ADAMTS like 5	0.9762	9
ECHDC2	Enoyl-CoA hydratase domain containing 2	0.9762	33
PRXL2B	Peroxiredoxin like 2B	0.9762	33
STING1	Stimulator of interferon response cGAMP interactor 1	0.9524	33
EEF1AKMT3	EEF1A lysine methyltransferase 3	0.9524	33
CADM1	Cell adhesion molecule 1	0.9524	33
RSL24D1	Ribosomal L24 domain containing 1	0.9524	33
ARHGEF19	Rho guanine nucleotide exchange factor 19	0.9524	33
SLC43A1	Solute carrier family 43 member 1	0.9524	33
SLC26A11	Solute carrier family 26 member 11	0.9524	33
BORCS5	BLOC-1 related complex subunit 5	0.9524	33
EIF3CL	Eukaryotic translation initiation factor 3 subunit C like	0.9286	33
NOP58	NOP58 ribonucleoprotein	0.9286	9
UQCRB	Ubiquinol-cytochrome c reductase binding protein	0.9286	31
BAG3	BAG cochaperone 3	0.9286	31