Single cell type - ENSG00000286098 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ENSG00000286098
Gene descriptionⁱ Full gene name according to HGNC.	Novel protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocyte precursor - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Oligodendrocyte precursor cells, Astrocytes, Microglial cells, Oligodendrocytes, Excitatory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.96
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at transcript level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Oligodendrocyte precursor cells, Astrocytes, Microglial cells, Oligodendrocytes, Excitatory neurons)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ

HPA datasetⁱ

Lineage

Expression

Alphabetical

Immune cell type specificity: Low immune cell specificity

Monaco datasetⁱ

Lineage

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ENSG00000286098 is part of cluster 76 Oligodendrocyte precursor - Unknown function with confidenceⁱ 1
210 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CHURC1-FNTB	CHURC1-FNTB readthrough	0.9043	76
ZSWIM6	Zinc finger SWIM-type containing 6	0.8304	76
PEAK1	Pseudopodium enriched atypical kinase 1	0.8139	76
ZNF816-ZNF321P	ZNF816-ZNF321P readthrough	0.7793	76
XYLT1	Xylosyltransferase 1	0.7705	76
OLIG2	Oligodendrocyte transcription factor 2	0.7555	76
GRIK4	Glutamate ionotropic receptor kainate type subunit 4	0.7480	76
DGKG	Diacylglycerol kinase gamma	0.7413	34
MMP16	Matrix metallopeptidase 16	0.7344	76
TNR	Tenascin R	0.7338	76
OLIG1	Oligodendrocyte transcription factor 1	0.7259	76
NRCAM	Neuronal cell adhesion molecule	0.7239	34
GPR17	G protein-coupled receptor 17	0.7219	76
KIF13A	Kinesin family member 13A	0.7168	76
DSCAM	DS cell adhesion molecule	0.7112	76

IMMUNE CELLS

ENSG00000286098 is part of cluster 24 Non-specific - Transcription with confidenceⁱ 0.9
516 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NKIRAS1	NFKB inhibitor interacting Ras like 1	1.0000	24
ORC2	Origin recognition complex subunit 2	0.9762	24
LIAS	Lipoic acid synthetase	0.9762	24
KAT14	Lysine acetyltransferase 14	0.9762	24
DMAC1	Distal membrane arm assembly component 1	0.9762	24
PUS7	Pseudouridine synthase 7	0.9524	24
NRN1L	Neuritin 1 like	0.9524	24
CDNF	Cerebral dopamine neurotrophic factor	0.9524	24
ZNF382	Zinc finger protein 382	0.9524	24
FBL	Fibrillarin	0.9524	24
SNAPC1	Small nuclear RNA activating complex polypeptide 1	0.9524	24
TUT1	Terminal uridylyl transferase 1, U6 snRNA-specific	0.9286	24
DTD2	D-aminoacyl-tRNA deacylase 2	0.9286	24
UBQLN4	Ubiquilin 4	0.9286	43
OARD1	O-acyl-ADP-ribose deacylase 1	0.9286	24