Expression of RAN in urothelial cancer - The Human Protein Atlas

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

RAN is potential prognostic, high expression is unfavorable in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 279.85

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

632.1

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	1695.0
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	1639.2
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	1470.6
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	1419.8
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	1392.2
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	1391.9
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	1336.9
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	1318.3
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	1275.3
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	1248.6
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	1184.3
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	1182.0
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	1180.8
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	1179.9
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	1168.9
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	1148.1
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	1136.6
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	1136.5
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	1126.9
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	1121.2
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	1120.6
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	1073.4
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	1067.7
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	1066.6
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	1055.0
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	1035.0
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	1017.4
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	1013.0
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	1004.4
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	997.2
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	983.5
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	978.3
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	955.7
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	953.8
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	951.9
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	943.8
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	903.4
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	892.1
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	883.4
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	876.1
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	872.2
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	866.1
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	864.1
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	862.6
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	859.3
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	856.9
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	838.6
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	831.4
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	830.0
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	829.2
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	827.1
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	822.6
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	820.1
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	808.0
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	807.2
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	799.9
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	791.1
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	780.9
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	768.1
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	767.4
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	765.6
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	762.3
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	758.0
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	745.4
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	740.3
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	731.4
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	726.6
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	718.7
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	717.0
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	708.1
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	695.9
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	692.9
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	687.3
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	679.0
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	666.1
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	663.4
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	653.1
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	645.1
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	636.1
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	627.2
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	626.4
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	611.9
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	594.5
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	589.3
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	582.6
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	574.2
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	573.2
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	571.8
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	563.6
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	560.0
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	551.5
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	542.4
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	537.5
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	512.7
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	512.2
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	502.1
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	492.1
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	491.7
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	487.4
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	479.3
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	471.8
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	461.8
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	457.7
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	455.2
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	447.1
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	445.7
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	442.7
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	440.9
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	417.7
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	413.5
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	411.2
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	403.5
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	400.9
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	397.4
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	396.0
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	392.8
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	391.1
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	385.2
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	382.9
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	380.7
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	374.0
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	373.0
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	367.9
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	367.6
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	356.9
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	353.7
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	348.3
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	338.6
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	323.7
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	321.2
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	310.3
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	304.3
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	300.3
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	298.1
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	288.3
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	271.4
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	260.9
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	244.3
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	243.0
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	239.7
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	239.5
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	229.5
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	225.9
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	221.6
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	211.9
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	210.6
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	210.1
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	206.2
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	201.9
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	197.3
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	196.1
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	192.5
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	183.5
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	183.4
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	182.8
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	182.5
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	175.4
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	174.4
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	172.1
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	168.8
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	163.3
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	162.0
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	150.1
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	146.8
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	143.6
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	133.1
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	106.0
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	103.0
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	73.2
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UROTHELIAL CANCER - Protein expressionⁱ

Pending cancer tissue analysis