Expression of TPT1 in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

TPT1 is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 3762.78

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

4072.1

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	20320.8
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	10261.9
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	9736.3
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	9031.2
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	8829.8
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	8541.8
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	8288.2
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	7714.4
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	7265.2
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	7227.6
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	6801.1
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	6679.1
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	6570.3
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	6514.8
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	6345.0
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	6320.8
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	6238.2
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	6114.0
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	6013.7
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	5998.0
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	5951.7
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	5927.8
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	5763.4
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	5749.3
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	5724.2
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	5720.5
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	5711.5
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	5677.5
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	5572.3
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	5561.0
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	5556.3
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	5549.8
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	5528.5
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	5431.7
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	5404.2
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	5370.0
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	5248.7
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	5227.3
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	5208.4
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	5183.6
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	5110.2
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	5029.3
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	4991.6
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	4981.3
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	4962.3
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	4931.5
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	4912.8
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	4907.2
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	4842.8
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	4802.6
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	4787.3
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	4773.1
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	4696.2
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	4691.2
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	4656.8
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	4652.6
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	4622.8
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	4556.8
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	4545.3
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	4452.7
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	4417.9
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	4362.4
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	4304.7
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	4294.7
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	4178.1
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	4156.3
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	4153.7
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	4151.9
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	4135.8
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	4067.4
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	3952.8
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	3951.4
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	3938.3
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	3883.3
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	3851.7
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	3835.3
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	3831.1
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	3818.2
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	3788.5
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	3786.8
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	3738.8
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	3684.0
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	3670.6
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	3633.8
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	3628.4
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	3609.2
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	3602.9
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	3589.6
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	3560.3
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	3556.0
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	3479.0
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	3457.4
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	3454.6
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	3452.0
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	3450.8
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	3438.2
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	3420.3
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	3399.2
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	3398.5
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	3350.7
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	3345.0
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	3337.4
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	3335.1
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	3304.6
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	3293.8
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	3282.8
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	3254.1
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	3233.0
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	3190.6
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	3176.8
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	3176.4
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	3115.2
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	3104.6
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	3073.6
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	3064.3
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	3061.2
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	3050.1
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	3011.8
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	3009.0
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	2941.5
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	2937.7
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	2912.5
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	2903.7
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	2896.3
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	2881.9
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	2839.0
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	2811.7
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	2740.7
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	2734.6
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	2689.3
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	2634.2
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	2633.1
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	2547.6
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	2546.4
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	2506.6
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	2456.4
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	2432.0
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	2418.8
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	2400.9
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	2390.1
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	2377.9
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	2352.6
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	2263.6
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	2221.3
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	2174.3
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	2129.8
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	2103.8
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	2078.4
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	2066.6
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	2065.9
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	2030.7
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	2011.6
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	1993.7
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	1903.7
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	1838.1
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	1769.4
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	1757.1
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	1674.3
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	1666.3
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	1615.4
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	1605.9
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	1565.0
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	1534.6
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	1514.0
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	1466.0
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	1232.4
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	1222.6
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	1156.2
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	910.0
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA039437	Antibody HPA073929	Antibody CAB008364
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, High grade
Urothelial carcinoma, Low grade