Single cell type - RNASEK-C17orf49 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RNASEK-C17orf49
Gene descriptionⁱ Full gene name according to HGNC.	RNASEK-C17orf49 readthrough
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Pancreatic endocrine cells, Ductal cells, Exocrine glandular cells, Proximal enterocytes, Distal tubular cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.83
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Pancreatic endocrine cells, Ductal cells, Exocrine glandular cells, Proximal enterocytes, Distal tubular cells)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

RNASEK-C17orf49 is part of cluster 49 Non-specific - Transcription with confidenceⁱ 1
378 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NDUFV2	NADH:ubiquinone oxidoreductase core subunit V2	0.7472	45
TXNDC12	Thioredoxin domain containing 12	0.7110	49
GNG5	G protein subunit gamma 5	0.6993	45
RPL17	Ribosomal protein L17	0.6840	49
DDX47	DEAD-box helicase 47	0.6565	49
C18orf32	Chromosome 18 open reading frame 32	0.6513	11
DNAJC25-GNG10	DNAJC25-GNG10 readthrough	0.6386	49
EGLN2	Egl-9 family hypoxia inducible factor 2	0.6354	49
POLD4	DNA polymerase delta 4, accessory subunit	0.6290	5
GABARAP	GABA type A receptor-associated protein	0.6266	49
ERVK3-1	Endogenous retrovirus group K3 member 1	0.6104	49
NOP2	NOP2 nucleolar protein	0.6090	49
PDCD6	Programmed cell death 6	0.6076	49
ENSG00000284292	Novel protein, ARPC1A and ARPC1B readthrough	0.5997	49
SLC39A1	Solute carrier family 39 member 1	0.5991	45

IMMUNE CELLS

RNASEK-C17orf49 is part of cluster 38 Monocytes & Neutrophils - Degranulation with confidenceⁱ 0.97
501 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TAGLN2	Transgelin 2	0.9762	38
SPOPL	Speckle type BTB/POZ protein like	0.9762	38
QKI	QKI, KH domain containing RNA binding	0.9524	38
CACNB4	Calcium voltage-gated channel auxiliary subunit beta 4	0.9524	38
SERTAD3	SERTA domain containing 3	0.9524	38
NDUFB6	NADH:ubiquinone oxidoreductase subunit B6	0.9524	38
FURIN	Furin, paired basic amino acid cleaving enzyme	0.9524	38
CNPY3	Canopy FGF signaling regulator 3	0.9524	38
TRIM6	Tripartite motif containing 6	0.9524	38
GRN	Granulin precursor	0.9524	38
ANKRD50	Ankyrin repeat domain containing 50	0.9286	38
UBR4	Ubiquitin protein ligase E3 component n-recognin 4	0.9286	38
TAF10	TATA-box binding protein associated factor 10	0.9286	2
RNF130	Ring finger protein 130	0.9286	38
C9orf153	Chromosome 9 open reading frame 153	0.9286	38