Single cell type - DNAJC25-GNG10 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DNAJC25-GNG10
Gene descriptionⁱ Full gene name according to HGNC.	DNAJC25-GNG10 readthrough
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Paneth cells, Pancreatic endocrine cells, Exocrine glandular cells, Ductal cells, Erythroid cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.76
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enriched (neutrophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at transcript level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Paneth cells, Pancreatic endocrine cells, Exocrine glandular cells, Ductal cells, Erythroid cells)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enriched (neutrophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

DNAJC25-GNG10 is part of cluster 49 Non-specific - Transcription with confidenceⁱ 1
378 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GABARAP	GABA type A receptor-associated protein	0.7545	49
GNG5	G protein subunit gamma 5	0.6859	45
TXNDC12	Thioredoxin domain containing 12	0.6605	49
HAUS4	HAUS augmin like complex subunit 4	0.6479	49
EIF4EBP3	Eukaryotic translation initiation factor 4E binding protein 3	0.6478	49
RNASEK-C17orf49	RNASEK-C17orf49 readthrough	0.6386	49
GNG10	G protein subunit gamma 10	0.6137	49
IL10RB	Interleukin 10 receptor subunit beta	0.6112	49
SRXN1	Sulfiredoxin 1	0.6018	49
SUPT4H1	SPT4 homolog, DSIF elongation factor subunit	0.5975	49
MYG1	MYG1 exonuclease	0.5975	49
ABHD16A	Abhydrolase domain containing 16A, phospholipase	0.5965	49
NGRN	Neugrin, neurite outgrowth associated	0.5894	49
SLC39A1	Solute carrier family 39 member 1	0.5716	45
ENSG00000250349	Novel proline rich Gla (G-carboxyglutamic acid) 1 (PRRG1) and tetraspanin 7 (TSPAN7) protein	0.5699	49

IMMUNE CELLS

DNAJC25-GNG10 is part of cluster 21 Neutrophils - Unknown function with confidenceⁱ 0.99
492 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
INKA2	Inka box actin regulator 2	1.0000	21
USP10	Ubiquitin specific peptidase 10	1.0000	21
SOCS3	Suppressor of cytokine signaling 3	1.0000	21
STEAP4	STEAP4 metalloreductase	0.9762	21
CLDN5	Claudin 5	0.9762	4
LRG1	Leucine rich alpha-2-glycoprotein 1	0.9762	4
DEFA4	Defensin alpha 4	0.9762	21
S100A11	S100 calcium binding protein A11	0.9762	21
ACSL1	Acyl-CoA synthetase long chain family member 1	0.9762	4
ARL3	ADP ribosylation factor like GTPase 3	0.9762	4
DYSF	Dysferlin	0.9762	21
ST6GALNAC2	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	0.9762	4
SRGN	Serglycin	0.9762	21
TSHZ3	Teashirt zinc finger homeobox 3	0.9762	21
CSF3R	Colony stimulating factor 3 receptor	0.9762	21