Expression of FTH1 in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

FTH1 is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 2749.97

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

3868.3

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	18704.3
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	16101.6
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	15283.2
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	13818.1
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	11870.1
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	11294.9
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	11244.4
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	10471.7
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	8721.0
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	8519.0
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	8499.8
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	8435.2
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	8264.2
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	8176.8
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	8041.3
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	7652.4
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	7142.4
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	6995.6
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	6968.1
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	6821.4
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	6817.5
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	6713.7
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	6595.4
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	6528.8
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	6506.2
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	6366.4
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	6205.3
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	6155.4
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	6132.1
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	6043.5
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	5939.1
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	5864.0
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	5766.5
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	5611.0
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	5467.2
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	5440.5
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	5406.3
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	5348.4
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	5171.4
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	5114.4
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	5010.8
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	4978.7
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	4858.9
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	4814.5
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	4706.8
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	4667.2
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	4639.2
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	4633.6
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	4616.9
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	4419.2
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	4418.7
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	4396.3
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	4342.3
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	4340.3
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	4183.4
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	4156.7
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	4027.0
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	3912.4
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	3737.5
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	3721.5
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	3566.0
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	3536.1
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	3491.9
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	3490.9
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	3462.1
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	3437.8
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	3429.3
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	3406.8
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	3318.0
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	3259.6
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	3238.1
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	3220.0
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	3220.0
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	3183.2
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	3143.5
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	3121.9
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	3119.0
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	3058.4
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	3028.0
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	3015.8
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	3001.5
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	3000.9
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	2992.2
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	2985.6
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	2977.1
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	2966.3
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	2939.9
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	2926.5
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	2908.7
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	2898.1
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	2894.7
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	2871.7
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	2866.8
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	2823.8
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	2763.4
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	2736.6
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	2727.4
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	2714.8
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	2694.2
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	2681.9
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	2675.3
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	2660.9
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	2591.7
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	2581.5
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	2495.0
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	2428.2
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	2403.9
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	2383.9
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	2373.3
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	2363.4
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	2329.8
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	2303.0
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	2260.3
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	2258.9
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	2239.3
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	2229.3
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	2202.3
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	2193.0
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	2167.5
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	2071.1
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	2063.4
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	2028.6
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	2028.0
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	2024.1
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	2016.6
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	1999.3
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	1949.3
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	1916.5
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	1916.0
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	1891.6
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	1873.4
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	1852.8
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	1852.6
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	1848.2
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	1832.9
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	1823.9
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	1776.0
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	1752.9
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	1736.2
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	1716.8
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	1715.2
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	1670.0
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	1627.3
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	1622.2
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	1620.6
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	1461.5
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	1460.9
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	1444.5
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	1344.5
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	1336.9
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	1322.9
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	1309.3
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	1262.6
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	1255.0
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	1237.8
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	1179.8
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	1156.0
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	1145.9
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	1082.2
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	1068.5
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	1066.7
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	963.8
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	962.3
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	841.9
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	836.3
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	816.0
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	785.4
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	635.9
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	495.8
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody CAB008623
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, Low grade
Urothelial carcinoma, High grade