Expression of RPL38 in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

RPL38 is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 1620.49

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

2239.8

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	10526.0
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	5437.6
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	4683.9
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	4552.2
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	4508.5
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	4425.6
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	4420.9
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	4334.7
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	4047.1
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	3967.3
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	3848.8
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	3785.2
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	3737.1
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	3715.1
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	3634.5
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	3545.6
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	3525.0
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	3455.1
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	3453.1
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	3445.3
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	3425.2
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	3224.5
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	3157.3
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	3109.1
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	3076.3
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	3065.7
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	3047.5
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	3044.2
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	3030.6
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	2997.2
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	2960.9
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	2871.5
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	2862.3
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	2848.9
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	2840.9
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	2815.7
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	2782.0
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	2776.4
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	2762.9
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	2741.3
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	2711.5
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	2693.1
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	2690.4
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	2645.5
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	2624.1
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	2583.4
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	2566.3
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	2565.2
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	2560.8
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	2547.1
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	2536.6
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	2517.3
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	2508.6
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	2482.1
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	2473.5
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	2471.3
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	2432.9
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	2413.8
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	2407.5
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	2401.1
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	2397.7
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	2382.2
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	2365.4
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	2357.9
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	2349.0
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	2334.7
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	2323.7
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	2297.2
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	2293.3
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	2283.8
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	2265.3
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	2253.8
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	2251.3
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	2244.3
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	2229.6
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	2220.4
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	2207.1
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	2187.3
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	2177.5
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	2175.8
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	2143.6
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	2120.0
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	2111.4
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	2111.4
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	2096.6
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	2093.3
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	2086.4
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	2067.3
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	2046.4
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	2032.7
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	2023.1
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	2013.0
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	1999.6
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	1985.2
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	1978.0
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	1975.8
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	1968.1
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	1967.5
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	1944.4
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	1939.3
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	1935.4
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	1923.5
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	1922.1
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	1908.4
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	1881.8
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	1867.8
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	1838.2
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	1833.9
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	1804.8
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	1798.6
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	1797.4
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	1794.6
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	1784.6
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	1712.3
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	1710.8
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	1675.3
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	1669.1
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	1626.5
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	1614.5
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	1603.7
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	1572.5
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	1555.3
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	1551.0
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	1531.4
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	1517.1
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	1489.4
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	1464.4
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	1455.7
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	1450.8
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	1448.8
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	1442.3
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	1440.1
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	1425.6
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	1413.8
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	1387.1
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	1372.1
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	1366.8
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	1350.1
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	1330.9
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	1308.1
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	1298.6
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	1289.8
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	1256.8
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	1256.1
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	1250.5
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	1219.2
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	1198.6
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	1177.6
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	1170.9
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	1168.0
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	1166.2
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	1166.0
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	1148.9
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	1136.1
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	1104.4
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	1072.7
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	1047.9
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	1034.1
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	1033.9
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	1026.2
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	998.4
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	988.3
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	914.0
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	776.6
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	774.8
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	693.3
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	689.9
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	671.1
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	615.0
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA052543
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, High grade
Urothelial carcinoma, Low grade
Urothelial carcinoma, NOS