Cancer-associated protein fetal and adult testis expressed 1 (gene: FATE1) is mapped to reproductive supporting cells in normal testis tissue using multiplex immunohistochemistry (mIHC/IF)...Read more

This month, the expression of beta-cell-associated transcription factor PDX1 within the endocrine pancreas is displayed through multiplex immunohistochemistry (mIHC/IF)...Read more

T cells are central drivers of inflammation across autoimmune and inflammatory diseases, yet current therapies inadequately target pathogenic T-cell pathways, limiting durable disease control. In a recent study published in Signal Transduction and Targeted Therapy, a team led by Thomas Helleday and Theodora Manolakou, identified a novel, targetable transcriptional-metabolic axis that sustains inflammatory T-cell responses. In an interview by Gustav Ceder, Helleday discusses the novel findings and ongoing lines of research...Read more

A new article in Protein Science describes the HPA Multiplex tissue resource, a spatial proteomics effort adding a new layer of high-resolution protein expression data to the HPA portal. The article presents both the methodology and the biological value of the resource, providing a scalable framework for in-depth spatial proteomics profiling of human tissues...Read more

Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder associated with high morbidity and early mortality. Rapidly progressive cell death of upper and lower motor neurons in the brain as well as in the spinal cord leads to loss of voluntary muscle control. Within a few years of diagnosis, patients lose the ability to move, speak, eat and breath without mechanical support. There is no cure for ALS, with current treatments merely aiming at slowing disease progression and improving symptoms...Read more