Expression of RPS13 in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

RPS13 is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 425.78

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

1067.4

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	3725.8
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	3720.2
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	2863.5
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	2489.1
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	2452.0
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	2420.1
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	2405.0
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	2279.6
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	2253.6
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	2229.4
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	2155.8
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	2107.7
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	2088.5
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	2073.4
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	2019.1
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	1961.0
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	1939.2
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	1918.1
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	1904.9
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	1887.8
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	1828.6
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	1809.7
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	1776.1
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	1774.4
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	1617.8
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	1605.5
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	1597.0
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	1593.8
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	1591.7
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	1590.0
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	1573.8
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	1559.0
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	1541.5
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	1534.2
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	1522.8
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	1519.8
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	1515.2
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	1499.6
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	1465.9
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	1415.7
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	1411.5
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	1408.6
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	1406.1
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	1403.0
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	1394.1
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	1387.6
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	1385.9
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	1381.9
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	1380.3
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	1360.9
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	1351.6
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	1349.9
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	1339.1
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	1333.3
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	1330.7
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	1323.2
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	1321.1
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	1302.2
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	1287.4
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	1278.0
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	1277.3
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	1268.8
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	1263.5
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	1263.3
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	1255.0
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	1244.8
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	1237.1
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	1235.2
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	1233.0
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	1229.1
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	1212.2
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	1211.9
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	1198.0
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	1195.5
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	1169.5
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	1151.2
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	1149.0
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	1146.5
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	1143.7
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	1137.3
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	1100.7
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	1100.5
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	1089.3
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	1054.4
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	1047.3
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	1047.1
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	1037.2
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	1028.8
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	1021.3
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	1002.7
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	997.9
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	991.3
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	983.6
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	980.4
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	968.2
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	968.1
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	964.8
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	951.0
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	949.1
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	938.3
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	926.8
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	919.0
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	912.6
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	908.2
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	900.1
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	893.6
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	891.1
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	888.8
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	863.9
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	857.3
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	841.5
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	836.9
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	803.0
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	792.8
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	748.0
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	683.8
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	661.0
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	638.8
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	632.8
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	614.7
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	602.6
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	591.6
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	584.2
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	556.2
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	527.2
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	427.1
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	426.4
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	425.2
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	407.0
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	398.3
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	395.5
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	389.2
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	371.9
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	362.9
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	358.2
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	349.1
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	332.5
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	326.9
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	322.3
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	320.2
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	316.9
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	312.2
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	308.0
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	287.6
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	259.8
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	259.1
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	246.6
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	240.0
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	238.7
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	238.7
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	226.7
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	217.4
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	216.0
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	203.0
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	201.5
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	194.6
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	189.9
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	167.0
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	161.1
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	142.0
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	141.9
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	116.7
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	113.6
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	106.9
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	98.4
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	93.2
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	0.0
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	0.0
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	0.0
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA005985
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, High grade
Urothelial carcinoma, Low grade