Expression of RPS6 in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

RPS6 is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 1665.37

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

2885.5

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	24140.7
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	10823.0
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	8510.5
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	8005.9
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	7610.1
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	7339.1
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	6585.0
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	6284.4
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	6167.3
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	5491.8
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	5319.8
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	5302.7
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	5152.1
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	5108.6
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	5029.7
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	5005.2
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	4896.7
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	4657.6
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	4604.7
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	4560.0
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	4423.3
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	4415.1
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	4341.4
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	4128.1
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	4106.0
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	4042.7
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	4003.6
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	3972.2
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	3848.2
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	3669.0
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	3609.3
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	3604.5
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	3589.8
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	3572.7
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	3506.5
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	3494.1
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	3448.5
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	3434.0
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	3418.4
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	3310.6
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	3284.2
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	3276.5
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	3275.6
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	3223.6
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	3167.7
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	3160.6
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	3152.0
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	3142.3
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	3131.9
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	3069.4
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	3053.4
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	3033.3
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	2996.7
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	2987.6
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	2939.3
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	2936.9
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	2900.8
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	2854.4
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	2839.6
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	2805.0
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	2784.4
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	2759.4
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	2756.0
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	2719.1
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	2711.6
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	2711.2
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	2706.0
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	2697.0
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	2685.2
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	2682.2
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	2665.2
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	2659.5
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	2647.0
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	2639.0
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	2608.4
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	2589.0
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	2581.5
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	2545.1
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	2485.6
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	2480.6
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	2450.4
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	2449.2
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	2443.2
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	2422.3
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	2414.0
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	2391.8
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	2374.1
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	2368.7
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	2368.1
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	2321.0
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	2314.3
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	2297.2
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	2287.5
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	2256.3
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	2243.9
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	2235.8
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	2216.7
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	2159.6
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	2130.1
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	2112.3
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	2108.9
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	2092.8
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	2060.7
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	2058.7
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	2050.8
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	2036.0
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	2026.7
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	1989.3
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	1959.8
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	1957.9
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	1957.2
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	1925.4
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	1921.4
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	1913.2
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	1911.8
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	1888.2
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	1882.5
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	1872.0
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	1856.5
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	1856.0
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	1838.4
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	1828.4
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	1801.2
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	1795.3
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	1786.9
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	1777.2
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	1775.5
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	1759.8
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	1756.8
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	1749.7
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	1730.3
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	1729.7
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	1696.7
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	1674.6
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	1667.3
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	1663.4
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	1644.1
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	1626.6
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	1591.6
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	1573.5
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	1566.0
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	1510.8
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	1501.8
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	1488.2
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	1461.4
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	1428.0
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	1420.6
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	1403.8
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	1402.5
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	1396.5
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	1380.9
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	1333.1
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	1324.9
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	1294.1
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	1292.6
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	1264.4
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	1243.8
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	1243.0
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	1218.9
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	1209.0
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	1174.3
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	1173.1
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	1082.4
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	1074.1
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	1071.2
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	1000.8
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	955.5
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	947.7
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	874.7
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA031153	Antibody CAB004027
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, Low grade
Urothelial carcinoma, High grade