In an article published in PNAS, researchers have used the recombinant expression of more than 2000 Human Secretome Project proteins to investigate the factors influencing recombinant protein expression in CHO cells...Read more

The ability to degrade intracellular proteins in a controlled manner is an important cellular function. It is utilized to remove and recycle unnecessary, damaged and/or harmful components, which is an essential ability to maintain cellular homeostasis and health. The most well-known routes to selective degradation of proteins are proteasomal degradation and selective autophagy. In both pathways, proteins targeted for degradation are marked polyubiquitination (polyUb), with chains that are linked at lysine K48 and K63, respectively...Read more

Sperm head structural protein cylicin 1 (gene: CYLC1) is visualized in late stage spermatogenesis with multiplex immunohistochemistry (mIHC/IF)...Read more

A new study has mapped the distinct molecular "fingerprints" that 59 diseases leave in an individual's blood protein - which would enable blood tests to discern troubling signs from those that are more common. Publishing today in Science, an international team of researchers mapped how thousands of proteins in human blood shift as a result of aging and serious diseases, such as cancer and cardiovascular and autoimmune diseases...Read more

Ion channels are pore-forming membrane proteins that selectively facilitate the rapid, passive movement of specific ions across various cell membranes and play an important role in many of our organ systems. In the Human Protein Atlas, the voltage-gated ion channels are represented by more than 100 genes from nine different subcategories based on their selectivity and the ions they conduct...Read more