An article in PNAS describes how hypoxia and the elimination of peroxisomes drives HCC dedifferentiation, a hallmark of malignancy and a challenge for therapy. The E3 ubiquitin ligase RNF126 is identified as a hypoxia-inducible switch that determines peroxisomal fate and links the hypoxic microenvironment to loss of hepatocyte differentiation...Read more

A new study published in Nature Communications by researchers from the Human Protein Atlas presents a high-resolution spatial map of proteins associated with motile cilia in the human fallopian tube, providing new insights into reproductive biology, infertility and cilia-related disease. All data from the study are publicly available in the Tissue Resource of the Human Protein Atlas...Read more

The differences in blood protein levels during childhood and early adulthood were recently explored in an article published in Nature Communications...Read more

In a review article published in Pharmacological reviews the current knowledge of molecular features, functions, and opportunities for therapeutic targeting of human and mammalian aGPCRs is summarised...Read more

In a study published in Journal of Proteome Research, >180 proteins have been spatially mapped to specific subcellular compartments in cells with motile cilia using multiplex immunohistochemistry. The high-resolution data is available in the HPA Tissue resource, and aids in further functional mapping of proteins with limited evidence...Read more