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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX CHOROID PLEXUS HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA
MIDBRAIN OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Consensus:2534.3 nTPM
HPA Brain:2020.0 nTPM
GTEx:2534.3 nTPM
FANTOM5:9292.6 Scaled Tags Per Million
Pig:854.7 nTPM
Mouse:371.7 nTPM
Allen mouse:12.2 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

2020.0
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 1613.6
2666 Male, age 74, left hemisphere 2144.4
1870 Female, age 42, unknown 2103.7
1830 Male, age 51, unknown 1984.5
1833 Male, age 53, unknown 1954.8
2411 Female, age 72, unknown 1952.8
2019 Male, age 18, unknown 1695.5
2828 Female, age 72, unknown 1576.8
1827 Male, age 72, unknown 1059.6
2219 Male, age 76, both hemispheres 961.7
2586 Male, age 75, left hemisphere 702.3
Dorsal raphe nucleus
nTPM: 1051.4
2750 Male, age 76, both hemispheres 1546.4
2016 Female, age 72, unknown 1195.3
1828 Male, age 53, unknown 1101.0
2298 Female, age 72, unknown 749.1
2047 Male, age 72, unknown 665.0
Inferior colliculus
nTPM: 939.1
1848 Female, age 42, unknown 1032.4
2849 Male, age 72, unknown 960.5
1890 Male, age 53, unknown 931.9
2097 Female, age 72, unknown 831.7
Median raphe nucleus
nTPM: 1289.5
2220 Male, age 76, midline 1289.5
Periaquaductal grey, anterior
nTPM: 776.8
1947 Male, age 18, unknown 968.0
1795 Male, age 51, unknown 725.0
2502 Female, age 75, unknown 637.3
Periaquaductal grey, dorsal
nTPM: 785.9
2464 Female, age 72, unknown 953.6
2850 Male, age 76, both hemispheres 917.3
1831 Male, age 72, unknown 886.9
1840 Male, age 53, unknown 385.9
Periaquaductal grey, lateral
nTPM: 917.3
2053 Male, age 18, unknown 943.4
2272 Male, age 74, both hemispheres 913.1
2140 Male, age 76, both hemispheres 895.5
Pretectal area
nTPM: 1022.6
1815 Male, age 53, unknown 1434.6
1817 Female, age 42, unknown 1271.0
2316 Male, age 76, right hemisphere 1102.3
2667 Female, age 75, unknown 1092.4
2273 Male, age 74, both hemispheres 1063.1
2407 Male, age 75, both hemispheres 1034.3
2825 Male, age 18, unknown 1003.8
2007 Male, age 72, unknown 952.2
2224 Female, age 72, unknown 915.0
1944 Female, age 72, unknown 762.0
1816 Male, age 51, unknown 617.6
Red nucleus
nTPM: 2020.0
1821 Female, age 72, unknown 2620.5
1904 Male, age 53, unknown 2514.2
1865 Male, age 51, unknown 2495.6
1954 Female, age 42, unknown 2234.4
2227 Male, age 72, unknown 2232.9
2503 Female, age 72, unknown 2204.6
2769 Male, age 72, unknown 2184.2
2785 Male, age 18, unknown 2030.1
2823 Male, age 76, right hemisphere 1988.8
2725 Female, age 75, unknown 1356.5
2588 Male, age 74, left hemisphere 1274.0
2584 Male, age 75, left hemisphere 1104.0
Substantia nigra
nTPM: 1148.1
2409 Female, age 72, unknown 1455.0
1851 Male, age 51, unknown 1413.5
1889 Female, age 72, unknown 1354.8
2699 Male, age 18, unknown 1272.2
2583 Male, age 75, right hemisphere 1139.0
1941 Male, age 53, unknown 1070.2
2590 Female, age 75, unknown 1061.3
2241 Male, age 72, unknown 1033.4
1916 Female, age 42, unknown 973.2
2665 Male, age 74, both hemispheres 708.1
Superior colliculus
nTPM: 1317.4
1913 Female, age 42, unknown 2094.3
2668 Female, age 75, unknown 2041.7
1995 Male, age 72, unknown 1911.9
2587 Male, age 74, left hemisphere 1538.8
1839 Male, age 51, unknown 1247.2
1796 Male, age 53, unknown 1128.3
1895 Male, age 76, right hemisphere 889.6
2087 Female, age 72, unknown 853.1
2664 Male, age 75, both hemispheres 758.9
2261 Male, age 18, unknown 710.2
Ventral tegmental area
nTPM: 1471.6
2223 Female, age 72, unknown 2410.6
2410 Female, age 72, unknown 1633.9
1915 Female, age 42, unknown 1268.3
2218 Male, age 76, both hemispheres 1207.4
2021 Male, age 53, unknown 1184.3
1942 Male, age 51, unknown 1124.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

2534.3
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 2534.3
Samples: 139

Max nTPM: 8165.0
Min nTPM: 707.9
Std nTPM: 1578.7
Median nTPM: 2069.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 8165.0
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 7969.8
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 7832.8
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 7231.6
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 7162.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 6269.8
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 6219.4
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 6174.6
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 5644.4
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 5496.2
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 5476.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 5323.8
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 5027.9
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 4975.1
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 4808.6
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 4503.6
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 4267.6
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 3977.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 3836.3
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 3789.7
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 3774.7
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 3726.8
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 3666.6
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 3659.7
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 3643.9
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 3613.8
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 3579.7
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 3546.3
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 3400.1
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 3374.1
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 3352.5
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 3230.8
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 3179.8
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 3127.4
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 3108.8
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 3074.0
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 2964.4
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 2901.0
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 2872.3
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 2869.4
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 2854.2
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 2778.3
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 2769.6
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 2769.3
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 2764.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 2719.8
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 2682.2
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 2672.0
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 2668.7
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 2540.1
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 2468.8
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 2436.8
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 2392.6
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 2321.5
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 2312.5
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 2310.9
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 2310.8
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 2256.6
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 2242.1
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 2236.5
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 2218.7
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 2197.5
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 2191.7
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 2170.9
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 2128.7
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 2103.7
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 2099.7
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 2097.9
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 2095.0
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 2069.7
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 2065.5
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 2045.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 2006.1
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 1963.6
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 1930.9
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 1878.2
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 1874.1
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 1873.7
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 1868.1
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 1867.1
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 1854.0
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 1842.7
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 1835.8
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 1834.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 1740.1
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 1739.3
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 1721.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 1702.6
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 1695.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 1693.0
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 1689.6
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 1688.0
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 1682.2
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 1681.7
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 1661.7
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 1643.5
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 1622.0
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 1593.4
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 1563.8
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 1561.4
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 1542.1
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 1529.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 1518.8
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 1512.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 1506.5
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 1492.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 1487.6
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 1465.8
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 1425.0
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 1413.7
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 1387.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 1386.8
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 1323.6
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 1300.5
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 1291.0
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 1287.8
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 1278.4
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 1241.7
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 1224.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 1219.0
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 1212.7
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 1172.6
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 1133.9
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 1127.4
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 1103.7
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 1093.8
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 1088.1
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 1082.3
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 1012.0
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 991.3
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 976.9
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 909.5
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 868.6
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 815.7
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 786.2
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 784.2
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 728.1
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 724.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 707.9
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MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Max subtype Scaled Tags Per Millioni

Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

9292.6
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 9292.6
FF:10158-103A5 76 years, female 9292.6

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

854.7
Pig sample Sample description nTPM
Substantia nigra
nTPM: 716.9
Samples: 4

Max nTPM: 1119.7
Min nTPM: 494.6
Sample A Female 752.2
Sample B Female 494.6
Sample C Male 501.1
Sample D Male 1119.7
Midbrain
nTPM: 854.7
Samples: 4

Max nTPM: 2005.5
Min nTPM: 366.9
Sample A Female 2005.5
Sample B Female 654.3
Sample C Male 391.9
Sample D Male 366.9
Periaqueductal gray
nTPM: 470.0
Samples: 3

Max nTPM: 530.1
Min nTPM: 377.2
Sample B Female 502.8
Sample C Male 377.2
Sample D Male 530.1
Superior colliculi
nTPM: 652.7
Samples: 4

Max nTPM: 798.2
Min nTPM: 391.2
Sample A Female 798.2
Sample B Female 391.2
Sample C Male 671.4
Sample D Male 750.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

371.7
Mouse sample Sample description nTPM
Midbrain
nTPM: 371.7
Samples: 4

Max nTPM: 403.8
Min nTPM: 340.0
Sample A Male 355.1
Sample B Male 340.0
Sample C Female 387.9
Sample D Female 403.8

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Max subtype Expression energyi

Max subtype Expression energy is the value for the subtype with the largest average Expression energy across the subtype samples.

12.2
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 12.2
72182998 Antisense, RP_050927_03_A08, Mouse strain C57BL/6J (56 days, male) 12.2
74357575 Antisense, RP_050927_03_A08, Mouse strain C57BL/6J (56 days, male) 10.4

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The Human Protein Atlas

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.


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